Gene interactions and pathways from curated databases and text-mining

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HLA-DRB1 — SP1

Text-mined interactions from Literome

Sun et al., Oncol Rep 2008 (Carcinoma, Hepatocellular...) : These data allowed us to draw a conclusion that 8-Cl-Ado enhanced DR5 expression is regulated by Sp1 binding to the -198/-189 cis-element in DR5 promoter without affecting NF-kappaB activity in the hepatoma cells
Kim et al., Mol Cancer Ther 2010 (Carcinoma, Hepatocellular...) : beta-Ionone enhances TRAIL induced apoptosis in hepatocellular carcinoma cells through Sp1 dependent upregulation of DR5 and downregulation of NF-kappaB activity
Moon et al., Mol Cancer Ther 2010 (Carcinoma, Hepatocellular...) : Butein sensitizes human hepatoma cells to TRAIL induced apoptosis via extracellular signal regulated kinase/Sp1 dependent DR5 upregulation and NF-kappaB inactivation