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IL6 — SP3

Text-mined interactions from Literome

Ehlting et al., Biochem J 2005 : In the present study, we show that mutation of this GC-rich element abolishes IL-6 dependent transcriptional activation of the SOCS3 promoter and that Sp3 ( specificity protein 3 ), a ubiquitously expressed transcription factor, but not Sp1 binds to this GC-rich motif, suggesting that Sp3 is involved in the regulation of SOCS3 expression
Porée et al., J Biol Chem 2008 (Osteoarthritis) : Indeed, IL-6 and/or sIL-6R inhibit Sp1 and Sp3 expression and their binding activity to the 63-bp promoter