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NOTCH2 — SPEN

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SPEN — NOTCH2 (colocalization, biochemical) Havugimana et al., Cell 2012

Text-mined interactions from Literome

Oswald et al., Mol Cell Biol 2005 : We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP mediated repression of Notch target genes
Doroquez et al., Mech Dev 2007 : At least in part due to loss of Spen dependent down-regulation of Notch signaling, loss of spen also dampens EGFR signaling as evidenced by reduced activity of MAP kinase ( MAPK )