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EGF — SPHK1

Text-mined interactions from Literome

Johnstone et al., Placenta 2005 : EGF also activates sphingosine kinase-1 (SPHK-1) , which converts sphingosine to sphingosine-1-phosphate, and its inhibition with dimethyl sphingosine ( DMS ) increased trophoblast death ... Inhibition of SPHK-1 also did not affect EGF stimulated phosphorylation of PI-3 kinase, Akt, ERK1/2 or p38 but inhibition of PI-3 kinase with a specific inhibitor LY294002 partly ( 40 % ) inhibited the EGF stimulated increase in SPHK-1 activity
Sarkar et al., FEBS Lett 2005 (Breast Neoplasms...) : Downregulation of SphK1 in MCF-7 cells reduced EGF- and serum stimulated growth and enhanced sensitivity to doxorubicin, a potent chemotherapeutic agent
Döll et al., Biochim Biophys Acta 2005 (Breast Neoplasms...) : The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7
Paugh et al., FASEB J 2008 (Glioblastoma) : EGF induced rapid phosphorylation of c-Src and PKCdelta and concomitant translocation of PKCdelta as well as SphK1 to the plasma membrane ... Down-regulation of PKCdelta abolished EGF induced SphK1 translocation and up-regulation of PAI-1 by EGF ; whereas, down-regulation of PKCalpha had no effect on the EGF induced PAI-1 activation but enhanced its basal expression ... Similarly, inhibition of c-Src activity by PP2 blocked both EGF induced translocation of SphK1 and PKCdelta to the plasma membrane and up-regulation of PAI-1 expression
Martin et al., J Biol Chem 2009 : IGFBP-3 potentiated EGF stimulated EGF receptor activation and DNA synthesis, and this was blocked by inhibitors of SphK activity or small interference RNA mediated silencing of SphK1, but not SphK2, expression
Estrada-Bernal et al., J Neurooncol 2011 (Brain Neoplasms...) : As the EGFR gene is often overexpressed and mutated in GBM, and EGFR has been shown to regulate SphK1 in some cell types, we examined the effect of EGF signaling and the constitutively active EGFRvIII mutant on SphK1 in GBM cells
Kharel et al., Biochem J 2011 : However, SphK1 inhibition did diminish EGF ( epidermal growth factor ) -driven increases in S1P levels and Akt ( also known as protein kinase B ) /ERK ( extracellular-signal regulated kinase ) phosphorylation
Rius et al., FEBS Lett 1997 (Pheochromocytoma) : In contrast, epidermal growth factor and insulin-like growth factor-1, which stimulate proliferation of PC12 cells, induced only small and transient increases in sphingosine kinase activity