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RHOA — SRC

Pathways - manually collected, often from reviews:

• KEGG Adherens junction: SRC → RHOA (protein-protein, inhibition)
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/RasGAP/p190RhoGAP complex (PTK2-YES1_SRC_FYN-RASA1-ARHGAP35) → RHOA/GDP complex (RHOA) (modification, activates) Arthur et al., Curr Biol 2000, Arthur et al., Mol Biol Cell 2001, Holinstat et al., J Biol Chem 2006, Playford et al., Exp Cell Res 2008, Tomar et al., J Cell Sci 2009
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/RasGAP/p190RhoGAP complex (PTK2-YES1_SRC_FYN-RASA1-ARHGAP35) → RHOA/GTP complex (RHOA) (modification, activates) Arthur et al., Curr Biol 2000, Arthur et al., Mol Biol Cell 2001, Holinstat et al., J Biol Chem 2006, Playford et al., Exp Cell Res 2008, Tomar et al., J Cell Sci 2009
  Evidence: mutant phenotype, assay
• Reactome Reaction: RHOA → SRC (reaction) Wahl et al., J Cell Biol 2000, Dickson et al., Curr Opin Neurobiol 2001, Sahin et al., Neuron 2005, Le Boeuf et al., Mol Biol Cell 2006

Text-mined interactions from Literome

Arthur et al., Curr Biol 2000 : Integrin engagement suppresses RhoA activity via a c-Src dependent mechanism ... Here we show that integrin engagement initially inactivates RhoA , in a c-Src dependent manner, but has no effect on Cdc42 or Rac1 activity
Baisden et al., Oncogene 2001 : Lastly, dominant positive RhoA ( V14 ) will block the ability of AFAP-110 ( Deltalzip ) from inducing actin filament rosettes, but does not inhibit Src activation
Salsmann et al., J Biol Chem 2005 : Finally, alphaIIbbeta3 dependent RhoA stimulation and cell spreading, but not cell attachment, are Src dependent and phosphoinositide 3-kinase independent and are inhibited by the Src antagonist PP2
Veettil et al., J Virol 2006 : Inhibition of Src activation by CdTxB and reduction of RhoA activation by Src inhibitors suggest that KSHV induced Src is involved in RhoA activation, which in turn is involved in a feedback sustained activation of Src
Kim et al., Small 2009 : The results indicate that this microenvironment effect on the biphasic RhoA activation in RMCs is mediated by Src and actomyosin machinery
Putnam et al., Cell communication and signaling : CCS 2009 : Inhibition of Src signaling was sufficient to restore normal actin architecture, and resulted in decreased p190RhoGAP phosphorylation and enhanced RhoA activity
Bhoopathi et al., Cell Signal 2011 (Medulloblastoma...) : Transfection with SPARC siRNA reversed Src mediated disruption of the cytoskeleton organization as well as dephosphorylation of cofilin and activation of Rho A
Balanis et al., Mol Biol Cell 2011 : Expression of an inactive ß3 integrin subunit abolishes p190RhoGAP tyrosine phosphorylation, demonstrating a mechanistic link between ß3 integrin activated Src and EGFR regulation of the RhoA inhibitor
Yeh et al., PloS one 2012 : The inhibition of Src/Vav2 attenuated the HSG mediated RhoA activation and EC proliferation but exhibited nominal effects on ECs on LSG
Boscher et al., Mol Biol Cell 2013 (Breast Neoplasms...) : Direct activation of integrin with Mn ( 2+ ) induces galectin-3, ILK, and Src dependent RhoA activation and caveolin-1 phosphorylation
Gomes et al., PloS one 2013 : The characterization of downstream molecular targets of c-Met activation, involved in the invasive phenotype, revealed increased phosphorylation of FAK and Src proteins and activation of Cdc42, Rac1 and RhoA GTPases
Ushio-Fukai et al., Mol Pharmacol 1999 : Thus, we provide evidence here that Gbetagamma as well as Galpha12 subunits mediate AT1 receptor coupling to tonic PLD activation via pp60(c-src) dependent mechanisms, and that RhoA is involved in these signaling pathways in rat VSMCs