Gene interactions and pathways from curated databases and text-mining

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SRC — WAS

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gross et al., Blood 1999 (Wiskott-Aldrich Syndrome) : Tyrosine phosphorylation of WASp was blocked by Src family kinase inhibitors and reduced by treatment with wortmannin and in patients with X-linked agammaglobulinemia ( XLA ), a condition caused by a lack of functional expression of Btk
Chellaiah et al., J Cell Physiol 2009 : Therefore, Src mediated phosphorylation of cortactin and WASP as well as the formation of WASP.cortactin.Arp2 complex and sealing ring were reduced in these osteoclasts