Gene interactions and pathways from curated databases and text-mining

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MMP1 — SSFA2

Text-mined interactions from Literome

Yasuda et al., Lab Invest 2003 (Arthritis, Rheumatoid) : Inhibition studies using protein kinase inhibitors ( PD98059 and SB203580 ) showed that those MAPK pathways contributed to MMP up-regulation by COOH-HBFN-f and CS-1 ... Thus, the present results have clearly shown that COOH-HBFN-f and CS-1 stimulate MMP production in association with activation of MAPK pathways in RSF
Tat et al., J Rheumatol 2010 (Osteoarthritis, Knee) : CS1 was much less efficient at reducing the catabolic markers and in the absence of IL-1ss, it significantly increased IL-6 and MMP-1