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IL15 — STAT1

Text-mined interactions from Literome

Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Lee et al., J Exp Med 1999 : Interestingly, interleukin (IL)-7 selectively activated STAT1 and induced MHC class I in mature T but not B cells
Strengell et al., J Immunol 2003 : We also show that IL-15 activated the binding of STAT1 , STAT3, STAT4, and STAT5 to the regulatory sites of the IFN-gamma gene
Zhang et al., Cytokine 2008 : Furthermore, IL-15 augmented the expression of cytotoxic effector molecules ( TRAIL and Perforin ) and the phosphorylation of STAT1 and ERK1/2, which may also contribute the NK lysis
García et al., J Immunol 1998 : Moreover, we showed that this increase in IFN-gamma could be explained by the dual activation of STAT1 and STAT4 by IL-15 and IL-12, respectively