Gene interactions and pathways from curated databases and text-mining

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HSPB1 — STAT3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Song et al., Biochem Biophys Res Commun 2004 (Breast Neoplasms) : Our results showed that heat shock 27kDa protein ( HSP27 ) was markedly induced by Stat3-C expression ... Further analysis demonstrated that phosphorylation of HSP27 at serine residue 78 was induced by Stat3-C in TERT breast cells as well as in MCF-10A and MDA-MB-453 breast cells
Cao et al., Circ Res 2006 : An increased association of STAT-5B with STAT-3 occurred in response to thrombin and adenovirus mediated expression of dnSTAT-3 suppressed thrombin induced Hsp27 and FGF-2 induction, DNA synthesis and motility in VSMC ... Together, these results indicate that thrombin induced VSMC growth and motility require STAT-5B/STAT-3 dependent expression of Hsp27 and FGF-2
Sims et al., PloS one 2013 : Imatinib reverses doxorubicin resistance by affecting activation of STAT3 dependent NF-?B and HSP27/p38/AKT pathways and by inhibiting ABCB1