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STAT3 — TNFSF11
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
O'Brien et al., J Biol Chem 1999
:
Moreover,
dn-STAT3 blocked the ability of either IL-6 + soluble IL-6 receptor or oncostatin M to induce
RANKL
Mori et al., Int Immunol 2011
(Arthritis, Experimental...) :
STAT3 activation also induced expression of receptor activator of nuclear factor kappa B ligand ( RANKL ), a cytokine essential for osteoclastogenesis, and STAT3 deficiency or pharmacological inhibition
promoted significant reduction in expression of both IL-6 family cytokines and
RANKL in vitro
Kim et al., Arthritis Rheum 2012
(Arthritis, Rheumatoid) :
IL-22 induced
RANKL expression was
down-regulated significantly by the inhibition of p38 MAPK/NF-?B or
JAK-2/STAT-3 signaling
Li et al., Biochem Biophys Res Commun 2013
:
Interestingly, AG490 partly inhibited
RANKL induced phosphorylation of Ser ( 727 ) in
STAT3