Gene interactions and pathways from curated databases and text-mining

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STAT3 — TNFSF11

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

O'Brien et al., J Biol Chem 1999 : Moreover, dn-STAT3 blocked the ability of either IL-6 + soluble IL-6 receptor or oncostatin M to induce RANKL
Mori et al., Int Immunol 2011 (Arthritis, Experimental...) : STAT3 activation also induced expression of receptor activator of nuclear factor kappa B ligand ( RANKL ), a cytokine essential for osteoclastogenesis, and STAT3 deficiency or pharmacological inhibition promoted significant reduction in expression of both IL-6 family cytokines and RANKL in vitro
Kim et al., Arthritis Rheum 2012 (Arthritis, Rheumatoid) : IL-22 induced RANKL expression was down-regulated significantly by the inhibition of p38 MAPK/NF-?B or JAK-2/STAT-3 signaling
Li et al., Biochem Biophys Res Commun 2013 : Interestingly, AG490 partly inhibited RANKL induced phosphorylation of Ser ( 727 ) in STAT3