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CD28 — STK11

Text-mined interactions from Literome

Cantrell et al., Semin Immunol 2002 : Protein kinase B (PKB) [ 1-5 ] is a serine/threonine kinase that is activated by cytokines, antigen receptors, the costimulator CD28 and chemokines in lymphocytes
Arimura et al., J Biol Chem 2004 : Both CD28 and its relative, inducible costimulator (ICOS), have a binding motif for phosphatidylinositol 3-kinase (PI3K) in their cytoplasmic tail, and the binding of PI3K leads to activation of a serine/threonine kinase , Akt
Parry et al., Biochem J 1997 : This study therefore demonstrates that ( 1 ) a CD28 activated serine/threonine kinase distinct from both PKC and PI 3-kinase mediates ligation stimulated CD28 phosphorylation, and ( 2 ) the PMA stimulated down-regulation of the coupling of CD28 to PI 3-kinase is not due to PMA stimulated phosphorylation of CD28