Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MAPK1
→
SULF1
(decreases, SULF1 Activity, MAPK1 Activity)
Evidence: Re-expression of HSulf-1 in ovarian cancer cell lines resulted in diminished HSPG sulfation, diminished phosphorylation of receptor tyrosine kinases that require sulfated HSPGs as co-receptors for their cognate ligands, and diminished downstream signaling through the extracellular signal-regulated kinase pathway after treatment with fibroblast growth factor-2 or heparin-binding epidermal growth factor.