Xu et al., J Card Fail 2008
(Disease Models, Animal...) :
Febuxostat blunted the TAC induced increases in nitrotyrosine ( indicating reduced myocardial oxidative stress ), p-Erk ( Thr202/Tyr204 ), and p-mTOR ( Ser2488 ), with no effect on total Erk or total mTOR
Suarez et al., Am J Physiol Cell Physiol 2010
(Cardiomegaly...) :
Interestingly, T3 administration dramatically canceled TAC induced ERK phosphorylation ( 36 % lower compared with control )