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TCF12 — TNF

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Guo et al., Am J Physiol 1999 (Necrosis) : C2 ceramide did not mimic the effects of TNF-alpha on the activation of c-Jun NH2-terminal protein kinase and nuclear factor-kappaB transcription factor
Manna et al., Biochem Pharmacol 1999 : Suppression of tumor necrosis factor activated nuclear transcription factor-kappaB , activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone
Myokai et al., Proc Natl Acad Sci U S A 1999 : A novel lipopolysaccharide induced transcription factor regulating tumor necrosis factor alpha gene expression : molecular cloning, sequencing, characterization, and chromosomal assignment
Otsuka et al., Cancer Res 1999 (Glioma) : TNF-alpha activates a transcription factor , nuclear factor-kappaB (NF-kappaB), which induces a wide variety of genes and causes pleiotrophic responses
Jaffray et al., J Surg Res 2000 (Liver Diseases...) : Serum tumor necrosis factor (TNF) protein ( ELISA ), hepatic TNF mRNA ( reverse transcription polymerase chain reaction ), and hepatic activation of the transcription factor nuclear factor kappa B ( electrophoretic mobility shift assay ) were also determined
Tolando et al., Free Radic Biol Med 2000 : Because Se supplementation decreases cytokine induced NF-kappaB activity, whereas added H ( 2 ) O ( 2 ) is inactive and catalase does not affect the activation induced by TNF-alpha, it is concluded that only intracellularly generated H ( 2 ) O ( 2 ) has a role in transcription factor activation by both TNF-alpha and IL-1beta
Nagaki et al., Hepatology 2000 : Tumor necrosis factor alpha (TNF-alpha) binding to the TNF receptor (TNFR) initiates apoptosis and simultaneously activates the transcription factor , nuclear factor-kappaB (NF-kappaB), which suppresses apoptosis by an unknown mechanism
Miyoshi et al., Am J Pathol 2001 (Cholestasis...) : Electrophoretic mobility gel shift assay and immunohistochemistry for NF-kappaB in BDL tumor necrosis factor-receptor 1 knockout mice demonstrated hepatocyte NF-kappaB activation, suggesting that tumor necrosis factor-alpha was not responsible for the activation of this transcription factor
Frost et al., Toxicol Appl Pharmacol 2001 : Propanil inhibits tumor necrosis factor-alpha production by reducing nuclear levels of the transcription factor nuclear factor-kappab in the macrophage cell line ic-21
Haridas et al., Proc Natl Acad Sci U S A 2001 : This study examines the effect of a triterpene mixture ( F094 ) and a single molecular species ( avicin G ) isolated from the mixture on tumor necrosis factor (TNF) induced activation of nuclear transcription factor-kappaB ( NF-kappaB ) in Jurkat cells ( human T cell leukemia )
You et al., Invest Ophthalmol Vis Sci 2002 : Exposure of various concentrations of LTA up to 24 hours did not lead to activation of NF-kappaB, whereas TNF-alpha potently induced this transcription factor
Jeong et al., Cytokine 2002 : Expression of TNF-alpha and IL-6 was regulated by a transcription factor , nuclear factor (NF)-kappaB
Chandra et al., Chem Biol Interact 2003 : Stimulation of the VECs with TNF-alpha led to an increase in the DNA binding activity of the transcription factor , nuclear factor-kappa binding protein ( NF-kappaB ) and the induction of the adhesion molecule ( ICAM)-1
Zhang et al., Free Radic Biol Med 2003 : Furthermore, treatment of HAEC with 0.5 mM DFO or NC completely inhibited TNFalpha induced activation of the transcription factor , specificity protein-1 (SP-1), but only partially inhibited or did not affect activation of other transcription factors known to regulate adhesion molecule expression, i.e., nuclear factor kappaB (NFkappaB), activator protein-1 (AP-1), and interferon regulatory factor-1 (IRF-1)
Broussard et al., Endocrinology 2003 : TNFalpha also impairs the ability of IGF-I to induce expression of a key myogenic transcription factor , myogenin
Punzón et al., Int Immunopharmacol 2003 : At the molecular level, EXPLY-37 did not inhibit the activation of the nuclear factor kappa B (NF-kappaB) transcription factor by TNF
Tomsig et al., Biochem J 2004 : The construct was found to reduce activation of the transcription factor NF-kappaB ( nuclear factor-kappaB ) by TNF-alpha
Chen et al., Arterioscler Thromb Vasc Biol 2004 : Carvedilol inhibits tumor necrosis factor-alpha induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells
Tamaoki et al., Am J Med 2004 (Chronic Disease...) : Macrolides inhibit the production of many proinflammatory cytokines, such as interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor-alpha , perhaps by suppressing the transcription factor nuclear factor-kappaB or activator protein-1
Zhu et al., Eur J Immunol 2005 (Inflammatory Bowel Diseases) : In the colons, a TNF-alpha inducing transcription factor , LPS induced TNF-alpha factor (LITAF), was inhibited by 1,25D3, but not by calcium
Alikhani et al., J Biol Chem 2005 : These results indicate that TNF induces activation of the FOXO1 transcription factor , which acts as a master switch to control apoptosis
Siore et al., Am J Physiol Lung Cell Mol Physiol 2005 (Disease Models, Animal...) : We monitored pulmonary vascular resistance, oxygenation, neutrophil count, lung edema as reflected by wet-dry weights of lung tissue, perfusate concentrations of TNF-alpha , IL-6, and 8-isoprostane ( a marker of oxidative stress ), and activation of the transcription factor ( NF-kappaB ) in lung tissue before and for 2 h after endotoxin
Ajuwon et al., J Nutr 2005 : Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes
Huber et al., Placenta 2006 : EMSA indicated TNFalpha induced binding of the inflammatory transcription factor to an NFkappaB consensus sequence and to the NFkappaB recognition site located in the PAI-1 promoter
Cohen-Lahav et al., Nephrol Dial Transplant 2006 : The aim of the present study is to examine whether this vitamin D inhibition of TNFalpha is mediated by its major transcription factor , nuclear factor-kappaB (NFkappaB)
Ke et al., Am J Physiol Lung Cell Mol Physiol 2006 : Given the fact that the transcription factor nuclear factor of activated T cells ( NFAT ) plays an important role in the regulation of TNF-alpha and can also be activated by ROS, in this study we investigated the potential role of ROS in silica induced NFAT activity as well as TNF-alpha expression in Cl41 cells
Gray-Schopfer et al., Cancer Res 2007 (MAP Kinase Signaling System...) : The survival mechanism requires nuclear factor-kappaB (NF-kappaB) transcription factor activity, which is strongly induced by TNF-alpha in these cells
Ruiz et al., J Nutr 2007 (Ileitis) : Quercetin inhibits TNF induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells
Takei et al., Mol Biol Cell 2008 (Neuroblastoma...) : We find that NGF can induce TNF-alpha synthesis through the nuclear factor-kappaB transcription factor
Samuel et al., Pancreatology 2008 (Disease Models, Animal...) : In additional in vitro studies, we show that cholecystokinin- or TNF-alpha stimulated nuclear transcription factor kappa-B activation in AR42J cells is inhibited by dominant negative ERK2
Sheikh et al., Hepatology 2008 (Hepatitis C...) : This transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand
Huang et al., Biochem Biophys Res Commun 2008 : Lipopolysaccharide induced TNF-alpha factor ( LITAF ), a transcription factor , can regulate tumor necrosis factor alpha (TNF-alpha) transcription
Di Giuseppe et al., PloS one 2009 (Silicosis) : TNFalpha signaling is mediated by the transcription factor , Nuclear Factor (NF)-kappaB, which regulates genes controlling several physiological processes including the innate immune responses, cell death, and inflammation
Nikolaidis et al., Shock 2010 : In addition, lung injury in the Ron TK-deficient ( TK ( -/- ) ) mice was associated with increased activation of the transcription factor , nuclear factor-kappaB (NF-kappaB), and significantly increased intrapulmonary expression of TNFalpha
Pollastri et al., Chem Biol Drug Des 2009 : We have screened a library of natural products against an assay measuring TNF-alpha secretion in lipopolysaccharide stimulated THP-1 cells, seeking compounds capable of interfering with the TNF-alpha inducing transcription factor lipopolysaccharide induced TNF-alpha factor
Li et al., Cancer Lett 2010 (Colorectal Neoplasms...) : In the search of the molecular mechanisms responsible for the sensitization effect of chrysin, we discovered that such sensitization is closely associated with the inhibitory effect of chrysin on TNFalpha mediated nuclear transcription factor-kappaB ( NF-kappaB ) activation
Trinh et al., Arch Pharm Res 2009 (Pruritus) : These curcuminoids also inhibited degranulation, protein expression of TNF-alpha and IL-4, and transcription factor NF-kappaB activation in IAC induced RBL-2H3 cells
Zhang et al., Biochem Biophys Res Commun 2010 (Inflammation) : In the present research, we showed that levels of SIRT1 mRNA and protein expression increased in TNF-alpha treated VSMCs. Overexpression of the p65/RelA subunit of NF-kappaB, a TNF-alpha activated inflammatory transcription factor , in A7r5 cells, upregulated SIRT1 mRNA and protein expression as well as SIRT1 promoter activity, while knockdown of endogenous p65/RelA expression by RNAi not only led to a decrease in SIRT1 's basal protein expression and promoter activity, but almost abolished the TNF-alpha induced elevation of SIRT1 protein expression and SIRT1 promoter activity
Messer et al., Cytokine 1990 : Tumor necrosis factor beta (TNF-beta) induces binding of the NF-kappa B transcription factor to a high-affinity kappa B element in the TNF-beta promoter
Kim et al., Phytother Res 2011 : Furthermore, 5-HMF significantly inhibited NF-?B transcription factor activation in TNF-a stimulated HUVECs
Shannon et al., Mol Cell Biol 1990 : These results demonstrate that NF-GMa is a novel transcription factor inducible by TNF-alpha and binds to a common element in HGF gene promoters
Krämer et al., J Biol Chem 1995 : Regulation of the human TNF promoter by the transcription factor Ets
Bergmann et al., J Immunol 1994 : This paper shows that a combination of adenosine and homocysteine potentiates TNF-alpha mediated cytotoxicity, but does not modulate activation of NF-kappa B transcription factor controlling the expression of various TNF-alpha-inducible genes
Rhoades et al., Virus Res 1996 : The adenoviral transcription factor , E1A 13S, trans-activates the human tumor necrosis factor-alpha promoter
Manna et al., J Biol Chem 1998 : Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1
Manna et al., J Immunol 1998 : TNF induced activation of another nuclear transcription factor , AP-1, was suppressed by IL-13
Abu-Amer et al., J Biol Chem 1998 : Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa Balpha
Tomita et al., J Hypertens 1998 (Inflammation) : To determine whether the transcription factor nuclear factor-kappaB mediated expression of these genes involved in the inflammatory response of endothelial cells to tumor necrosis factor-alpha , by using transcription factor decoy oligodeoxynucleotides
Handel-Fernandez et al., Int J Mol Med 1998 (Adenocarcinoma...) : Altered binding of the NF-GMa transcription factor is involved in the upregulated production of TNF-alpha by macrophages of mammary tumor bearing mice
Wang et al., Invest Ophthalmol Vis Sci 1999 : To determine whether nuclear transcription factor-kappaB ( NF-kappaB ) is activated in human retinal pigment epithelial ( hRPE ) cells in response to interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) , or interferon-gamma (IFN-gamma) alone or in combination and if so, whether expression of proinflammatory genes induced by these agents can be blocked by a proteasome inhibitor, MG-132, which inhibits the degradation of I kappaB, an NF-kappaB inhibitor, thereby preventing nuclear translocation of NF-kappaB