Gene interactions and pathways from curated databases and text-mining

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SDC2 — TCF15

Text-mined interactions from Literome

Dieudonné et al., Cancer Res 2010 (Bone Neoplasms...) : Wnt3a stimulation, beta-catenin activation, and TCF overexpression resulted in syndecan-2 repression, whereas Wnt inhibition using sFRP-1 increased syndecan-2 expression in U2OS cells
Dieudonné et al., J Bone Miner Res 2012 (Bone Neoplasms...) : We previously showed that Wnt/ß-catenin/T-cell factor ( TCF ) activation are responsible for the repression of syndecan-2 , a key modulator of apoptosis and chemosensitivity in osteosarcoma cells, suggesting a role of Wnt signaling in chemoresistance ... Conversely, ß-catenin/TCF activation impaired syndecan-2 induction by doxorubicin, indicating that Wnt signaling is competing with the action of the cytotoxic drug