Gene interactions and pathways from curated databases and text-mining

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EDN1 — TCF3

Text-mined interactions from Literome

Kitta et al., Biochem J 2001 : Endothelin-1 induces phosphorylation of GATA-4 transcription factor in the HL-1 atrial-muscle cell line
Yanazume et al., J Biol Chem 2002 (Hypertrophy) : A zinc finger transcription factor , GATA-4, is activated by extracellular signal regulated kinase 1/2 and is required for the up-regulation of the endothelin-1 gene during myocardial cell hypertrophy
Clément et al., Free Radic Biol Med 2002 : Our previous study demonstrated that endothelin-1 induced a phosphorylation of GATA-4 transcription factor , which plays important roles in cardiac hypertrophy and failure
Wakabayashi et al., J Dermatol Sci 2013 (Lentigo) : Real-time RT-PCR and Western blotting of these NCM treated HEEs unexpectedly revealed that the EDN1+SCF stimulated steady-state levels of tyrosinase (TYR), TYR related protein-1, dopachrome tautomerase and PMEL17 as well as microphthalmia associated transcription factor ( MITF ) were significantly attenuated at the transcriptional and translational levels without any cytotoxic effects on keratinocytes and melanocytes in the HEEs