Gene interactions and pathways from curated databases and text-mining

◀ Back to RAC1

RAC1 — TERF2IP

Text-mined interactions from Literome

Maillet et al., Nat Cell Biol 2003 (Alzheimer Disease) : We also show that Rac activation results from activation of Rap1 through the cAMP guanine nucleotide-exchange factor (GEF) Epac1
Arthur et al., J Cell Biol 2004 : Rap1a activates Rac1 and requires Rac1 to enhance spreading, whereas Rac1 induces spreading independently of Rap1
Sato et al., Cancer Sci 2005 : The activation of Cdc42 and Rac by the trans-interaction of nectin and nectin is mediated by c-Src, another small G protein, Rap1 , a Cdc42-GEF, FRG, and a Rac-GEF, Vav2 ... The trans-interaction of Necl-5 and nectin-3 also activates Rap1 through C3G, a Rap-GEF, and this activation of Rap1 is required for the activation of Cdc42 and Rac
Birukova et al., Exp Cell Res 2007 (Respiratory Distress Syndrome, Adult) : Prostaglandins PGE ( 2 ) and PGI ( 2 ) promote endothelial barrier enhancement via PKA- and Epac1/Rap1 dependent Rac activation
Guidetti et al., Journal of thrombosis and haemostasis : JTH 2009 : However, when phosphorylation of PLCgamma2 was blocked by the Src kinase inhibitor PP2, prevention of Rac1 activation significantly reduced PLCgamma2 activation, GTP-Rap1b accumulation, and alpha ( IIb ) beta3 stimulation
Malchinkhuu et al., Mol Biol Cell 2009 (Glioma) : The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) is required for the inhibitory ISO induced and Rap1B mediated actions on the migration, Rac1 activation, and Akt activation in response to LPA ... Thus, the PTEN mediated down-regulation of phosphatidylinositol 3-kinase activity may be involved in the regulation of Rap1B dependent inhibition of Rac1 activity
Stefanini et al., Arterioscler Thromb Vasc Biol 2012 : Whereas Rap1 signaling directly controls sustained Rac1 activation, Rac1 affects CalDAG-GEFI- and P2Y12 dependent Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively