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MET — TFE3
Text-mined interactions from Literome
Tsuda et al., Cancer Res 2007
(Sarcoma) :
Aberrant transcriptional
up-regulation of
MET by oncogenic
TFE3 fusion proteins represents another mechanism by which certain cancers become dependent on MET signaling
Parikh et al., Rare tumors 2009
:
TFE3 mediated direct transcriptional upregulation of the
Met tyrosine kinase receptor triggers dramatic activation of downstream signaling pathways including the protein kinase B ( Akt ) /phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) pathways