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AGTR1 — TGFB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AGTR1 → TGFB1 (increases)
  Evidence: TGF-1beta treatment significantly decreased miR-155 expression levels (Fig. 6A). Although TGF-1beta also up-regulated the expression of the hAT1R gene (Fig. 6B), the time course for the increased production of hAT1R mRNA did not correlate well with the time course for the enhanced synthesis of hAT1R protein levels since these values remained higher than expected at the 8 and 12 h time points (Fig. 6, C versus B). Therefore, the sustained increase in hAT1R protein levels cannot be accounted for b...

Text-mined interactions from Literome

Gurantz et al., Circ Res 1999 : Ang II, transforming growth factor-beta(1) , and basic fibroblast growth factor reduced AT(1) mRNA levels ( P < 0.02 )
Cenni et al., Biomaterials 2002 : The release of TGF-beta1 into the conditioned medium was increased significantly by CMW 1 extract at 1 h-curing, but was not changed significantly by CMW 1 extract at 7 day curing and by the extracts of the other cements, at both curing times
Lijnen et al., Am J Hypertens 2003 (Hypertension) : In these patients, AT(1)R antagonism and ACEI reduced these plasma TGF-beta(1) levels significantly
Tiede et al., Cardiovasc Res 2003 (Myocardial Infarction) : Instead, increased release of transforming growth factor beta 1 ( TGFbeta1 ) was detected by ELISA in response to AT(1)-receptor stimulation
Tower et al., Mol Hum Reprod 2005 : Transforming growth factor beta1 regulates angiotensin II type I receptor gene expression in the extravillous trophoblast cell line SGHPL-4 ... Extravillous trophoblast cells, SGHPL-4, were stimulated with 10 ng/ml TGFbeta1 +/- 100 ng/ml OSM for 24 h. Real-time PCR showed that AT1 expression increased 2.76-fold [ 95 % confidence interval ( CI ) = 1-6.74, P = 0.05 ] in response to TGFbeta1 and 4.21-fold ( 95 % CI = 1.33-11.76, P = 0.03 ) with TGFbeta1 + OSM
Martin et al., Am J Physiol Lung Cell Mol Physiol 2007 (MAP Kinase Signaling System) : TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways
Sun et al., J Neurol Sci 2009 (Muscular Dystrophies...) : The activation of AT1 may induce fibrous tissue formation through overexpression of TGF-beta1 , which potently activates fibrogenesis and suppresses regeneration
Ohta et al., Eur J Pharmacol 1994 (Hypertension) : Thus, angiotensin AT1 receptor may play an important role in the regulation of extracellular matrices and TGF-beta 1 expressions in SHR
Logan et al., J Endocrinol 1994 (Disease Models, Animal...) : Thyroid TGF-beta 1 mRNA levels substantially and progressively increased at 1 and 2 weeks of goitrogen treatment respectively, and remained above control levels at 4 and 10 weeks