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CA2 — THBS1
Text-mined interactions from Literome
Wieclawska et al., Eur J Haematol 2001
(Diabetes Mellitus, Type 2) :
Thrombospondin (TSP) , which is secreted from alpha-granules of activated platelets, binds to its surface receptor ( CD36 ) in the
presence of
Ca2+
Kinlough-Rathbone et al., Thromb Haemost 1983
:
Since aggregation and fibrinogen binding involving the glycoprotein IIb/IIIa complex are readily reversed by EDTA, and since
Ca2+ is
required for
thrombospondin binding to activated platelets, there may be a third type of platelet-platelet adherence that is not disrupted by EDTA ; this type of binding plays a greater role with human than with rabbit platelets
Gartner et al., Thromb Res 1984
:
These findings resolve the contradictions resulting from the apparent
requirement for free
Ca2+ in the binding of secreted
thrombospondin to the plasma membranes of platelets, the behavior of purified thrombospondin in hemagglutination assays and the characteristics of the endogenous lectin ( thrombospondin ) expressed by platelets stimulated with A23187 or gamma-thrombin
Tsao et al., J Biol Chem 1995
:
We now show that intact soluble
thrombospondin causes a transient
[Ca2+ ] i increase in IMR-90 fibroblasts