Gene interactions and pathways from curated databases and text-mining

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ICAM1 — THBS1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ICAM1 → THBS1 (increases)
    Evidence: A significant increase in ICAM-1 expression on HAEC was observed when monolayer cells were treated with rTSP-1 (Fig. 2A). The stimulatory effect of TSP-1 on HAEC was comparable with that of TNF-?.
  • OpenBEL Selventa BEL large corpus: ICAM1 → THBS1 (increases)
    Evidence: MFI for ICAM-1 on HUVEC were 230, 584, 692, 1278, and 1115 at 2, 4, 8, 17, and 24 h of stimulation with TNF-?. Likewise, maximum expression of VCAM-1 and ICAM-1 was also observed 17 h after the addition of TSP-1 (Fig. 1B).