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BMP2 — TLR4
Text-mined interactions from Literome
Su et al., J Biol Chem 2011
:
The aim of this study was to determine the effect of oxidized low density lipoprotein ( oxLDL ) on BMP-2 protein expression in human coronary artery endothelial cells ( CAECs ), the
roles of Toll-like receptor (TLR) 2 and
TLR4 in oxLDL induced
BMP-2 expression, and the signaling pathways involved ... The
roles of TLR2 and
TLR4 in oxLDL induced
BMP-2 expression were determined by pretreatment with neutralizing antibody, siRNA, and overexpression ... These findings underscore an important
role for TLR2 and
TLR4 in mediating the
BMP-2 response to oxLDL in human CAECs and indicate that these two immunoreceptors contribute to the mechanisms underlying atherosclerotic vascular calcification
Zeng et al., Arterioscler Thromb Vasc Biol 2013
(Aortic Valve Stenosis...) :
Aortic valve interstitial cells ( AVICs ) from stenotic valves express higher levels of
bone morphogenetic protein-2 in
response to
Toll-like receptor 4 stimulation