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PI3 — TLR5
Text-mined interactions from Literome
Rhee et al., J Biol Chem 2006
:
Here we dissected the biochemical mechanism by which
TLR5 engagement
mediates phosphatidylinositol 3-kinase (PI3K) activation in colonic epithelial cells
Yu et al., J Immunol 2006
:
We hypothesized that, analogous to the case for TLR4,
phosphoinositide 3-kinase (PI3K) might negatively
regulate TLR5 signaling
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007
(Inflammation) :
In this study, we determined whether
phosphoinositide 3-kinase (PI3K) , a negative
regulator of
TLR5 signaling, is involved in the cross talk between MUC1 and TLR5 using various genetically modified epithelial cell lines
Guiducci et al., J Exp Med 2008
:
Phosphatidylinositol-3 kinase (PI3K) has been shown to be
activated by
TLR triggering in multiple cell types ; however, its role in pDC function is not known
Watarai et al., Proc Natl Acad Sci U S A 2008
:
However, when coupled with Sema6D, a ligand for Plexin-A1, limited
TLR-stimulation resulted in PDC-TREM mediated DAP12 dependent phosphorylation of
phosphoinositide 3-kinase (PI3K) and extracellular regulated kinase (Erk) 1/2 at 6-9 h, and IFN-alpha was produced