Gene interactions and pathways from curated databases and text-mining

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PI3 — TLR5

Text-mined interactions from Literome

Rhee et al., J Biol Chem 2006 : Here we dissected the biochemical mechanism by which TLR5 engagement mediates phosphatidylinositol 3-kinase (PI3K) activation in colonic epithelial cells
Yu et al., J Immunol 2006 : We hypothesized that, analogous to the case for TLR4, phosphoinositide 3-kinase (PI3K) might negatively regulate TLR5 signaling
Kato et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation) : In this study, we determined whether phosphoinositide 3-kinase (PI3K) , a negative regulator of TLR5 signaling, is involved in the cross talk between MUC1 and TLR5 using various genetically modified epithelial cell lines
Guiducci et al., J Exp Med 2008 : Phosphatidylinositol-3 kinase (PI3K) has been shown to be activated by TLR triggering in multiple cell types ; however, its role in pDC function is not known
Watarai et al., Proc Natl Acad Sci U S A 2008 : However, when coupled with Sema6D, a ligand for Plexin-A1, limited TLR-stimulation resulted in PDC-TREM mediated DAP12 dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and extracellular regulated kinase (Erk) 1/2 at 6-9 h, and IFN-alpha was produced