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IRF1 — TLR7

Text-mined interactions from Literome

Schoenemeyer et al., J Biol Chem 2005 : Here we show that in contrast to IRF3 and IRF7, IRF5 is not a target of the TLR3 signaling pathway but is activated by TLR7 or TLR8 signaling
Nhu et al., J Endotoxin Res 2006 : Transcriptional regulation of lipopolysaccharide (LPS) induced Toll-like receptor ( TLR ) expression in murine macrophages : role of interferon regulatory factors 1 (IRF-1) and 2 ( IRF-2 ) ... Given that IRF-1 and IRF-2 counter-regulate the transcriptional activity of many genes, we hypothesized that IRF-1 and IRF-2 might also regulate TLR gene expression following LPS stimulation of murine macrophages
Severa et al., J Immunol 2007 : The induction of TLR7 in maturing DC was mainly a consequence of the transcriptional activity of IRF-1 , whose binding site was located within TLR7 promoter
Hickey et al., J Leukoc Biol 2008 : Adenylate cycalse toxin of Bordetella pertussis inhibits TLR induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses