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IL1B — TLR9
Text-mined interactions from Literome
Li et al., J Immunol 2007
:
Alum induced
IL-1beta and IL-18 production was not
due to enhancement of
TLR signaling but rather reflected caspase-1 activation and in mouse dendritic cells occurred in a MyD88 independent fashion
Dinarello et al., Immunity 2007
(Inflammation) :
Secretion of the proinflammatory cytokine
IL-1beta requires caspase-1 and
Toll-like receptor ( TLR ) signaling
Kim et al., Immunol Lett 2007
(Arthritis, Rheumatoid...) :
TLR stimulation of RA-FLS also
induced the production of
IL-1beta and TNF-alpha to a lesser extent ; however, it had no effect on IL-17 production ... Inhibition of
TLR induced
IL-1beta production, which partially reversed the upregulation of RANKL induced by TLR ligands
Ferwerda et al., J Leukoc Biol 2007
(Crohn Disease) :
TLR induced TNF-alpha,
IL-1beta , and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta
Villacres et al., J Viral Hepat 2008
(Hepatitis C, Chronic) :
To a lesser extent, tumour necrosis factor-alpha and
IL-1beta responses to
TLR stimulation were also compromised
Netea et al., Expert Opin Biol Ther 2008
(Inflammation) :
Monocytes can release active
IL-1 beta upon
stimulation with
TLR ligands alone
van de Veerdonk et al., J Infect Dis 2009
(Inflammation) :
The transcription of
IL-1beta was
induced through mannose receptor ( MR ), Toll-like receptor (TLR) 2, and dectin-1 but not through TLR4 and
TLR9
Hurst et al., Immunobiology 2009
(Antiphospholipid Syndrome) :
Determination of expression-levels using real-time RT-PCR showed significantly augmented
TLR dependent
IL-1beta and caspase-1 expression
Jung et al., Immunol Lett 2009
(Arthritis, Experimental...) :
These data show that TLR2,
TLR4 , and TLR6 ligation synergistically
stimulates the production of TNF-alpha and
IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model
Lamkanfi et al., J Biol Chem 2009
(Inflammation) :
IL-1beta secretion further
required the
Toll-like receptor ( TLR ) adaptors MyD88 and TRIF, and partially relied on TLR2
Kleinnijenhuis et al., Eur J Immunol 2009
:
In contrast,
TLR4 , TLR9 and TLR1 receptors are not
involved in
IL-1beta induction
Böni-Schnetzler et al., Endocrinology 2009
:
FFA induced
IL-1beta and KC expression in mouse islets was completely
dependent on the
IL-1R/Toll-like receptor ( TLR ) docking protein Myd88 and partly dependent on TLR2 and -4
Mayer-Barber et al., J Immunol 2010
(Tuberculosis, Pulmonary) :
Caspase-1 independent
IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not
require TLR signaling in vivo