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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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BCL10 — TNF

Text-mined interactions from Literome

Tamatani et al., J Biol Chem 1999 : Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons ... Expression of the mutant NFkappaB completely inhibited NFkappaB DNA binding activity and inhibited both TNF induced up-regulation of Bcl-2 and Bcl-x expression and neuroprotective effect
Bui et al., J Cell Biol 2001 : We conclude that NGF and TNF-alpha induce different signaling pathways in neurons to activate NFkappaB and bcl-x gene expression
Soeda et al., Life Sci 2001 : Moreover, crocin suppressed the TNF-alpha induced expression of Bcl-Xs and LICE mRNAs and simultaneously restored the cytokine induced reduction of Bcl-X ( L ) mRNA expression
Chandrasekar et al., J Biol Chem 2004 (Inflammation) : Treatment of HCMEC with IL-18 increases 1 ) NF-kappaB DNA binding activity ; 2 ) induces kappaB-driven luciferase activity ; 3 ) induces IL-1beta and TNF-alpha expression via NF-kappaB activation ; 4 ) inhibits antiapoptotic Bcl-2 and Bcl-X ( L ) ; 5 ) up-regulates proapoptotic Fas, Fas-L, and Bcl-X ( S ) expression ; 6 ) induces fas and Fas-L promoter activities via NF-kappaB activation ; 7 ) activates caspases-8, -3, -9, and BID ; 8 ) induces cytochrome c release into the cytoplasm ; 9 ) inhibits FLIP ; and 10 ) induces HCME cell death by apoptosis as seen by increased annexin V staining and increased levels of mono- and oligonucleosomal fragmented DNA
Yang et al., Zhonghua Gan Zang Bing Za Zhi 2005 : [ Bcl-xl blocks tumor necrosis factor alpha induced caspase 8 activation and apoptosis ]
Zhang et al., Arthritis Rheum 2005 (Arthritis, Experimental...) : Bcl-xL or Ets-2 overexpression protected osteoclasts from ALN induced apoptosis, and TNF stimulated Bcl-xL and Ets-2 expression in osteoclasts
Wang et al., Clin Cancer Res 2005 (Breast Neoplasms...) : Further investigation showed that silencing of hPEBP4 in MCF-7 cells promoted TNF-alpha induced stability of p53, up-regulation of phospho-p53ser15, p21waf/cip, and Bax, and down-regulation of Bcl-2 and Bcl-xL , which were shown to depend on extracellular signal regulated kinase 1/2 and c-jun NH2-terminal kinase activation by hPEBP4 silencing
Dhingra et al., Am J Physiol Heart Circ Physiol 2007 : The antioxidant Trolox modulated TNF-alpha induced changes in Bax/Bcl-xl , cell injury, and MAPKs
Gozzelino et al., Cell Res 2008 : However, Bcl-x ( L ) protein levels, but not those of Bcl-2, Bax and Bak, are reduced by ActD or TNF-alpha/ActD treatments
Antony et al., J Biol Chem 2010 : We found that either PP2A inhibitor okadaic acid or depletion of catalytic subunit alpha of PP2A ( PP2A/Calpha ) by small interfering RNA enhanced Bcl-x ( L ) phosphorylation when activated with hydrogen peroxide and tumor necrosis factor alpha induced oxidative stress
Bhattacharyya et al., J Biol Chem 2010 (Inflammation) : TNF-a induced the ubiquitination of TRAF2 ( TNF receptor associated factor 2 ), which interacts with NIK, and CGN induced phosphorylation of BCL10 , leading to increased NIK phosphorylation
Jäättelä et al., Oncogene 1995 (Breast Neoplasms) : Bcl-x and Bcl-2 inhibit TNF and Fas induced apoptosis and activation of phospholipase A2 in breast carcinoma cells
Slowik et al., Lab Invest 1997 : TNF + CHX killing is effectively blocked by transfected CrmA protein or treatment with Z-VAD.fmk peptide-both inhibitors of interleukin-1 converting enzyme-like proteases-but not by transfected antiapoptotic proteins Bcl-2, Bcl-XL , or A1 ... TNF + cer killing, which can affect more than 50 % of EC, is not effectively inhibited by CrmA or Z-VAD frank, but can be readily blocked by Bcl-2, Bcl-XL , or A1