Gene interactions and pathways from curated databases and text-mining

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STAT5A — TNF

Text-mined interactions from Literome

Klein et al., Shock 2003 (Burns...) : The changes in cytokine profiles after burn, particularly interleukin-1beta and macrophage inhibitory factor, appear to be mediated by C/EBP-beta and STAT-3, whereas after the induction of a sepsis, tumor necrosis factor and interleukin-6 are mainly mediated by STAT-5
Rehn et al., Acta Physiol Scand 2004 : Staining of the ganglionic cells with an antibody against the transcription factor STAT5 revealed that TNF-alpha induced a nuclear translocation of STAT5 in non-neuronal cells
DiFedele et al., Gastroenterology 2005 (Carcinoma, Hepatocellular...) : TNFalpha down-regulated GHR abundance and prevented GH-induced tyrosine phosphorylation of STAT5 in rat hepatocytes in culture
Ahmed et al., Am J Physiol Gastrointest Liver Physiol 2006 : TNF attenuated JAK2/STAT5 and ERK1/2 phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation
Storz et al., FEBS Lett 1998 : TNF inhibits insulin induced STAT5 activation in differentiated mouse muscle cells pmi28 ... TNF downregulated insulin induced insulin receptor kinase activity and insulin induced activation of the transcription factor STAT5