Gene interactions and pathways from curated databases and text-mining

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MAPK3 — TNFSF10

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Secchiero et al., Blood 2004 (MAP Kinase Signaling System) : Among the intracellular pathways investigated, TRAIL significantly stimulated the extracellular signal regulated kinase 1/2 ( ERK1/2 ) but not the p38/mitogen activated protein kinase ( MAPK ) or the c-Jun NH2-terminal kinase (JNK) pathway
Belyanskaya et al., Lung Cancer 2008 (Carcinoma, Small Cell...) : TRAIL induced SCLC cell proliferation was mediated by extracellular signal regulated kinase 1 and 2, and dependent on the expression of surface TRAIL-receptor 2 (TRAIL-R2) and lack of caspase-8, which is frequent in SCLC
Sun et al., Oncol Rep 2011 : Taken together, we show herein that the upstream molecule of the TRAIL induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8 dependent manner