Gene interactions and pathways from curated databases and text-mining

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BMP2 — TNFSF11

Text-mined interactions from Literome

Koide et al., Biochem Biophys Res Commun 1999 : It is noted that BMP-2 alone did cause an increase in the expression of both COX-2 and ODF genes ... Since BMP-2 alone induced the expression of COX-2 and ODF genes in osteoblast-like cells, it appears to be one of the regulating factors of osteoclastogenesis
Otsuka et al., Calcif Tissue Int 2003 : Since the formation of osteoclasts was inhibited dose-dependently by exogenous OPG, the expression of RANKL in response to BMP-2 appeared to be critical for the formation of osteoclasts
Wittrant et al., Int J Oncol 2006 (Bone Neoplasms...) : RANKL directly induces bone morphogenetic protein-2 expression in RANK expressing POS-1 osteosarcoma cells ... Results revealed a RANKL induced increase in ERK phosphorylation, as well as BMP-2 induction at the mRNA and protein levels, and a decrease of POS-1 cell proliferation in the presence of 10 ng/ml RANKL ... Moreover, a 2-fold molar excess of soluble RANK blocks the RANKL induced BMP-2 expression, demonstrating that the biological effects of RANKL observed in POS-1 cells are mediated by RANK
Usui et al., J Bone Miner Res 2008 (Fractures, Bone) : Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2 ... A reporter assay was used to determine whether BMP2 induced RANKL production is through transcriptional regulation of the RANKL promoter and whether it is mediated by Runx2 ... Deletion or mutation of Runx2 binding sites within the RANKL promoter or overexpression of a dominant negative Runx2 abolished BMP2- and Smad1 mediated activation of RANKL promoter activity ... Hypertrophic chondrocytes may regulate osteoclastogenesis at growth plates to remove calcified matrix through BMP induced RANKL expression
Fujita et al., Molecular cancer 2007 (Plasmacytoma) : Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2 induced osteoblast differentiation and expression of OPG, RANKL and M-CSF
Susperregui et al., J Cell Physiol 2008 : Similarly, PTHrP did not significantly modify the BMP regulated expression of RANKL or OPG, cytokines involved in osteoclastogenesis
Osako et al., Circ Res 2010 (Calcinosis...) : RANKL induced the calcification inducer bone morphogenetic protein-2 by human aortic endothelial cells ( HAECs ) and decreased the calcification inhibitor matrix Gla protein (MGP) in human aortic smooth muscle cells ( HASMCs ), as quantified by real-time PCR and Western blot analysis
Granholm et al., Bone 2013 : Moreover, the data show that BMP-2 not only stimulates osteoblastic differentiation but can also induce osteoclastogenesis through increased RANKL