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SMAD2 — TOB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yoshida et al., Cell 2000
:
Negative
regulation of
BMP/Smad signaling by
Tob in osteoblasts ... The results indicate that
Tob negatively
regulates osteoblast proliferation and differentiation by suppressing the activity of the receptor regulated
Smad proteins
Tzachanis et al., Nat Immunol 2001
:
Tob associated with Smad2 and Smad4 and
enhanced Smad DNA binding ... The inhibitory effect of
Tob on interleukin 2 (IL-2) transcription was not
mediated by blockade of NFAT, AP-1 or NF-kappaB transactivation but by enhancement of
Smad binding on the -105 negative regulatory element of the IL-2 promoter