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MMP2 — TP53
Text-mined interactions from Literome
Sun et al., Mol Carcinog 1999
(Neoplasm Metastasis) :
p53 transcriptionally
activates expression of the genes encoding epidermal growth factor receptor,
matrix metalloproteinase (MMP)-2 , cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Wang et al., Mol Carcinog 2000
:
Gamma-irradiation induces
matrix metalloproteinase II expression in a
p53 dependent manner ... Our results show that wild-type
p53 induced by ionizing radiation
caused a subsequent increase of
MMP-2 activity in U2-OS and RKO cells but not in MCF-7, HepG2, SAOS-2, or RKO-E6 cells
Toschi et al., J Invest Dermatol 2000
(Melanoma...) :
Wild-type
p53 gene transfer inhibits invasion and
reduces matrix metalloproteinase-2 levels in p53 mutated human melanoma cells
Fortunato et al., Am J Obstet Gynecol 2000
(Fetal Membranes, Premature Rupture...) :
Induction of
matrix metalloproteinase 2 may be a function of
p53 gene expression
increase in premature rupture of fetal membranes
Kunugi et al., Lab Invest 2001
(Wounds and Injuries) :
The proportion of p53 positive cells was high in epithelial cells from 1 to 14 days as MMP-2 levels were increased, suggesting that
p53 may be
responsible , at least in part, for the increase of
MMP-2
Ito et al., J Natl Cancer Inst 2002
(Neoplasm Invasiveness...) :
Glut-1 mediated
MMP-2 expression
involved the binding of the transcription factor
p53 but not Ets-1
Nemoto et al., Cell Biol Int 2007
:
Promoter analysis and gel shift assay showed that
p53 and Ets-1 were
involved in
MMP-2 expression in ornithine decarboxylase overexpressing transfectants
Xiao et al., J Cell Biochem 2009
(Melanoma) :
Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate ( VC-IP ) against ultraviolet-A ray induced injuries in human skin cells together with collagen retention,
MMP inhibition and
p53 gene repression
Chetty et al., Int J Cancer 2009
(Lung Neoplasms) :
We show that
MMP-2 inhibition prior to irradiation
reduced p53 phosphorylation, with a corresponding reduction in the expression of the p53 downstream target gene p21 ( Cip1/Waf1 )
Staun-Ram et al., Placenta 2009
:
p53 Mediates epidermal growth factor (EGF)
induction of
MMP-2 transcription and trophoblast invasion ... Inhibition of
p53 by antisense
reduced both basic and EGF- induced
MMP-2 expression ...
p53 mediates both basic and EGF induced
MMP-2 transcription
Zhang et al., J Mol Cell Cardiol 2011
(Heart Rupture...) :
PFTa increases
MMP-2 activity in a
p53 dependent manner, which seems a major contributor to instability of the forming scar and consequently leads to infarct progression and ventricular rupture
Chen et al., J Biol Chem 2012
(Breast Neoplasms...) :
A series of biochemical assays showed that S100A14
requires functional
p53 to affect
MMP2 transcription, and p53 potently transrepresses the expression of MMP2 ... Collectively, our data strongly suggest that S100A14 promotes cell motility and invasiveness by regulating the expression and function of
MMP2 in a
p53 dependent manner