Gene interactions and pathways from curated databases and text-mining

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MMP2 — TP53

Text-mined interactions from Literome

Sun et al., Mol Carcinog 1999 (Neoplasm Metastasis) : p53 transcriptionally activates expression of the genes encoding epidermal growth factor receptor, matrix metalloproteinase (MMP)-2 , cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Wang et al., Mol Carcinog 2000 : Gamma-irradiation induces matrix metalloproteinase II expression in a p53 dependent manner ... Our results show that wild-type p53 induced by ionizing radiation caused a subsequent increase of MMP-2 activity in U2-OS and RKO cells but not in MCF-7, HepG2, SAOS-2, or RKO-E6 cells
Toschi et al., J Invest Dermatol 2000 (Melanoma...) : Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53 mutated human melanoma cells
Fortunato et al., Am J Obstet Gynecol 2000 (Fetal Membranes, Premature Rupture...) : Induction of matrix metalloproteinase 2 may be a function of p53 gene expression increase in premature rupture of fetal membranes
Kunugi et al., Lab Invest 2001 (Wounds and Injuries) : The proportion of p53 positive cells was high in epithelial cells from 1 to 14 days as MMP-2 levels were increased, suggesting that p53 may be responsible , at least in part, for the increase of MMP-2
Ito et al., J Natl Cancer Inst 2002 (Neoplasm Invasiveness...) : Glut-1 mediated MMP-2 expression involved the binding of the transcription factor p53 but not Ets-1
Nemoto et al., Cell Biol Int 2007 : Promoter analysis and gel shift assay showed that p53 and Ets-1 were involved in MMP-2 expression in ornithine decarboxylase overexpressing transfectants
Xiao et al., J Cell Biochem 2009 (Melanoma) : Cytoprotective effects of the lipoidic-liquiform pro-vitamin C tetra-isopalmitoyl-ascorbate ( VC-IP ) against ultraviolet-A ray induced injuries in human skin cells together with collagen retention, MMP inhibition and p53 gene repression
Chetty et al., Int J Cancer 2009 (Lung Neoplasms) : We show that MMP-2 inhibition prior to irradiation reduced p53 phosphorylation, with a corresponding reduction in the expression of the p53 downstream target gene p21 ( Cip1/Waf1 )
Staun-Ram et al., Placenta 2009 : p53 Mediates epidermal growth factor (EGF) induction of MMP-2 transcription and trophoblast invasion ... Inhibition of p53 by antisense reduced both basic and EGF- induced MMP-2 expression ... p53 mediates both basic and EGF induced MMP-2 transcription
Zhang et al., J Mol Cell Cardiol 2011 (Heart Rupture...) : PFTa increases MMP-2 activity in a p53 dependent manner, which seems a major contributor to instability of the forming scar and consequently leads to infarct progression and ventricular rupture
Chen et al., J Biol Chem 2012 (Breast Neoplasms...) : A series of biochemical assays showed that S100A14 requires functional p53 to affect MMP2 transcription, and p53 potently transrepresses the expression of MMP2 ... Collectively, our data strongly suggest that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53 dependent manner