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INS — TPO

Text-mined interactions from Literome

Ortiz et al., J Biol Chem 1999 : The forkhead thyroid-specific transcription factor TTF-2 is the main mediator of thyrotropin and insulin regulation of thyroperoxidase (TPO) gene expression
Zarrilli et al., Mol Endocrinol 1990 (Cell Transformation, Neoplastic) : TPO and TG mRNAs are regulated by TSH and by insulin-like growth factor I (IGF-I) and/or insulin
Broqua et al., Biochem Pharmacol 1990 : Thus, insulin initially triggered a rise in plasma TRP ( without any change in liver TPO activity ) and then increased liver TPO activity whilst plasma TRP returned toward control levels
Gérard et al., Mol Endocrinol 1989 : In primary cultures, insulin is responsible for the basal level and for a part of forskolin induced TG transcription, whereas TPO transcription is not affected by insulin
Aza-Blanc et al., Mol Endocrinol 1993 : Insulin also stimulates TPO promoter activity, but the effect of this hormone is weaker and slower than that of TSH
Nascimento-Saba et al., Braz J Med Biol Res 1998 (Diabetes Mellitus, Experimental...) : These data suggest that insulin deficiency first reduces in vivo TPO activity during short-term experimental diabetes mellitus