◀ Back to MAP3K7

MAP3K7 — TRAF6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: O/k complex () → Complex of MAP3K7-TRAF6 (increases, MAP3K7/TRAF6 Activity) Mochida et al., Kokubyo Gakkai Zasshi 2000*
  Evidence: Here we report that ASK 1 binds to TAK 1 and dissociates TAK 1 from TNF receptor-associated factor 6 (TRAF 6), and inhibits TAK 1- and TRAF 6-, but not NF-kappa B-inducing kinase (NIK)-induced NF-kappa B activation
• BioCarta nf-kb signaling pathway: IL-1/IL-1R/MYD88/IRAK/TRAF6 complex (IL1A-IL1R1-MYD88-IRAK1-TRAF6) → TAB1/TAK1 complex (MAP3K7IP1-MAP3K7) (modification, activates)
  
• BioCarta toll-like receptor pathway: TRAF6 → Tak1/TAB1/TAB2 complex (MAP3K7-MAP3K7IP1-MAP3K7IP2) (modification, activates)
  
• KEGG Osteoclast differentiation: TRAF2/TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• KEGG Toll-like receptor signaling pathway: TRAF6 → MAP3K7 (protein-protein, activation)
• KEGG Toll-like receptor signaling pathway: Complex of RIPK1-TRAF6 → MAP3K7 (protein-protein, activation)
• KEGG Leishmaniasis: TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• KEGG Toxoplasmosis: TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• KEGG Measles: TRAF6 → Complex of MAP3K7-TAB2 (protein-protein, activation)
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → UBC13/UEV1A complex (UBE2N-UBE2V1) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: UBC13/UEV1A complex (UBE2N-UBE2V1) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, activates)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database p38 MAPK signaling pathway: TAK1 (MAP3K7) → TRAF6 (TRAF6) (modification, collaborate) Wang et al., Nature 2001, Cheung et al., EMBO J 2003, Shibuya et al., Science 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database p38 MAPK signaling pathway: TRAF6 (TRAF6) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Wang et al., Nature 2001, Cheung et al., EMBO J 2003, Shibuya et al., Science 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TAK1/TAB1/TAB2 complex (MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Li et al., Proc Natl Acad Sci U S A 2001
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BCR signaling pathway: TRAF6 (TRAF6) → CARD11/BCL10/MALT1/TAK1 complex (CARD11-BCL10-MALT1-MAP3K7) (modification, activates)
  
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → UBC13/UEV1A complex (UBE2N-UBE2V1) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, collaborate)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6/TAK1/TAB1/TAB2 complex (IRAK1-TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: UBC13/UEV1A complex (UBE2N-UBE2V1) → TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) (modification, activates)
  Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL1-mediated signaling events: TRAF6/TAK1/TAB1/TAB2 complex (TRAF6-MAP3K7-TAB1-TAB2) → IRAK (IRAK1) (modification, collaborate) Takaesu et al., Mol Cell 2000, Wang et al., Nature 2001, Jiang et al., Mol Cell Biol 2002
  Evidence: mutant phenotype, assay
• Reactome Reaction: TRAF6 → MAP3K7 (indirect_complex) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Takaesu et al., Mol Cell 2000, Ono et al., J Biol Chem 2001, Sun et al., Mol Cell 2004, Kanayama et al., Mol Cell 2004, Chen et al., Nat Cell Biol 2005, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Besse et al., J Biol Chem 2007*, Adhikari et al., Oncogene 2007, Xia et al., Nature 2009, Kulathu et al., Nature structural & molecular biology 2009*, Shibuya et al., Science 1996
• Reactome Reaction: TRAF6 → MAP3K7 (reaction) Kishimoto et al., J Biol Chem 2000, Sakurai et al., FEBS Lett 2000, Takaesu et al., Mol Cell 2000, Ono et al., J Biol Chem 2001, Sun et al., Mol Cell 2004, Kanayama et al., Mol Cell 2004, Chen et al., Nat Cell Biol 2005, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Brown et al., J Mol Biol 2005, Besse et al., J Biol Chem 2007*, Adhikari et al., Oncogene 2007, Xia et al., Nature 2009, Kulathu et al., Nature structural & molecular biology 2009*, Shibuya et al., Science 1996
• Reactome Reaction: TRAF6 → MAP3K7 (direct_complex)
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → Complex of IKBKG-CHUK-IKBKB-HSP90AA1 (activation)
  
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → MAPK1 (activation)
• WikiPathways EBV LMP1 signaling: Complex of MAP3K7-TAB1-MAP3K3-TRAF6 → MAPK8 (activation)
• WikiPathways IL17 signaling pathway: TRAF6 → MAP3K7 (activation)
• WikiPathways IL17 signaling pathway: TRAF6 → MAP3K7 (activation)
• WikiPathways Regulation of toll-like receptor signaling pathway: TRAF6 → MAP3K7 (activation)
• WikiPathways Regulation of toll-like receptor signaling pathway: TRAF6 → MAP3K7 (activation)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): TRAF6 → TAB1/MAP3K7/TAB2/TAB3 (activation)
• WikiPathways TLR4 Signaling and Tolerance: TRAF6 → Complex of MAP3K7-TAB2-TAB1 (activation)
  
• WikiPathways Toll-like Receptor Signaling Pathway: TRAF6 → MAP3K7 (activation)
• WikiPathways Toll-like Receptor Signaling Pathway: TRAF6 → MAP3K7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Cui et al., Mol Cell Biol 2012*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Ishitani et al., EMBO J 2003
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Mochida et al., J Biol Chem 2000*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Takaesu et al., Mol Cell Biol 2001*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Takaesu et al., Mol Cell 2000
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Ninomiya-Tsuji et al., Nature 1999*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Walsh et al., PloS one 2008*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Sorrentino et al., Nat Cell Biol 2008*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Frobøse et al., Mol Endocrinol 2006*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (direct interaction, enzymatic study) Xia et al., Nature 2009
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Jiang et al., J Biol Chem 2003
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Yamazaki et al., Science signaling 2009*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Jiang et al., Mol Cell Biol 2002
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Jiang et al., J Biol Chem 2003
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Minoda et al., Biochem Biophys Res Commun 2009*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Lee et al., Cell Mol Life Sci 2012*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (direct interaction, two hybrid) Gao et al., Cell Mol Life Sci 2009*
• IRef Biogrid Interaction: TRAF6 — MAP3K7 (physical association, affinity chromatography technology) Hirata et al., J Immunol 2006*
• MIPS CORUM TRAF6-TAK1 complex: TRAF6-TAK1 complex complex (MAP3K7-TRAF6) Frobøse et al., Mol Endocrinol 2006*
• IRef Corum Interaction: MAP3K7 — TRAF6 (association, coimmunoprecipitation) Frobøse et al., Mol Endocrinol 2006*
• IRef Dip Interaction: Complex of MAP3K7-IKBKB-TAB2-TNIK-TRAF6 (anti bait coimmunoprecipitation) Shkoda et al., PLoS Biol 2012
• IRef Hprd Interaction: Complex of 17 proteins Windheim et al., Mol Cell Biol 2008
• IRef Hprd Interaction: Complex of 65 proteins (in vivo) Tseng et al., Nat Immunol 2010
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Jiang et al., J Biol Chem 2003
• IRef Hprd Interaction: Complex of 82 proteins (in vivo) Tseng et al., Nat Immunol 2010
• IRef Hprd Interaction: TRAF6 — MAP3K7 (in vivo) Ninomiya-Tsuji et al., Nature 1999*, Sorrentino et al., Nat Cell Biol 2008*
• IRef Hprd Interaction: TRAF6 — MAP3K7 (in vitro) Ninomiya-Tsuji et al., Nature 1999*, Sorrentino et al., Nat Cell Biol 2008*
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Minoda et al., Biochem Biophys Res Commun 2009*
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Mizukami et al., Mol Cell Biol 2002*
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Takaesu et al., Mol Cell 2000
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Hirata et al., J Immunol 2006*
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Takaesu et al., Mol Cell Biol 2001*
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Mochida et al., J Biol Chem 2000*
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Ishitani et al., EMBO J 2003
• IRef Innatedb Interaction: MAP3K7 — TRAF6 (unknown, -) Jiang et al., J Biol Chem 2003
• IRef Intact Interaction: Complex of TAB3-TRAF6-MAP3K7 (association, anti tag coimmunoprecipitation) Jiang et al., J Biol Chem 2003
• IRef Intact Interaction: Complex of TAB1-TAB2-MAP3K7-TRAF6 (association, coimmunoprecipitation) Qian et al., J Biol Chem 2001*
• IRef Intact Interaction: MAP3K7 — TRAF6 (physical association, anti tag coimmunoprecipitation) Lamb et al., EMBO Rep 2009*
• IRef Intact Interaction: Complex of MAP3K7-TAB1-TRAF6 (association, coimmunoprecipitation) Ninomiya-Tsuji et al., Nature 1999*
• IRef Ophid Interaction: MAP3K7 — TRAF6 (aggregation, confirmational text mining) Ninomiya-Tsuji et al., Nature 1999*
• IRef Ophid Interaction: MAP3K7 — TRAF6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lee et al., J Biochem Mol Biol 2002 : The AP1 activation by TRAF2, TRAF5 , and TRAF6 was also greatly suppressed by the dominant negative TAK1 ... The AP1 activation by TRAF2, TRAF5, and TRAF6 was also greatly suppressed by the dominant negative TAK1
Kanayama et al., Mol Cell 2004 : TAK1 is in turn activated by TRAF6 , a RING domain ubiquitin ligase that facilitates the synthesis of lysine 63-linked polyubiquitin chains
Kim et al., J Biol Chem 2009 : We also show that TRAF6 and TAB2 are required for the interaction of TAK1 with TbetaRI and TGF-beta1 induced TAK1 activation in mouse mesangial cells
Lamb et al., EMBO Rep 2009 (Inflammation) : Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6 mediated Lys 63 ubiquitination
Galão et al., Cell Host Microbe 2012 (Inflammation) : Furthermore, recruitment of the TNF-receptor associated factor TRAF6 and activation of the mitogen activated protein kinase TAK1 are critical for signaling