Gene interactions and pathways from curated databases and text-mining

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PRKAB2 — TSC2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Brugarolas et al., Cancer Cell 2004 (Hamartoma...) : LKB1 activation by energy deprivation activates AMPK , which in turn phosphorylates and activates TSC2
Hahn-Windgassen et al., J Biol Chem 2005 : Currently, the Akt mediated phosphorylation of TSC2 and the inhibition of AMPK mediated phosphorylation of TSC2 are viewed as two separate pathways, which activate mTOR ... Our results demonstrate that Akt lies upstream of these two pathways and induces full inhibition of TSC2 and activation of mTOR both through direct phosphorylation and by inhibition of AMPK mediated phosphorylation of TSC2
Pan et al., Mol Cell Biochem 2008 : AMPK regulates the activation of TSC2 by phosphorylating TSC2
Sun et al., Proc Natl Acad Sci U S A 2008 : Consistent with a TSC-Rheb-PLD signaling cascade, AMPK and PI3K, both established regulators of TSC2 , appear to lie upstream of PLD as revealed by the effects of pharmacological inhibitors, and serum activation of PLD is also dependent on amino acid sufficiency
Zhu et al., J Virol 2012 (Circoviridae Infections) : AMPK and ERK1/2 positively regulate autophagy through negative control of the mTOR pathway by phosphorylating TSC2 in PCV2 infected PK-15 cells
Sviripa et al., Bioorg Med Chem Lett 2013 : AMPK also regulates lipid synthesis by inhibiting acetyl-CoA carboxylase (ACC) and regulates mTOR signaling by activating TSC2