Bai et al., J Neurosci 2003
:
2'-Amino-3'-methoxyflavone, an inhibitor of mitogen activated protein kinase kinase , which is a known inhibitor of NGF dependent differentiation in PC12 cells, suppressed the NGF dependent expression and nuclear translocation of TRX Kuster et al., Circulation 2005
(Hypertrophy) :
TRX1 overexpression inhibited the alphaAR stimulated phosphorylation of MEK1/2 , ERK1/2, and p90RSK and prevented cellular hypertrophy, sarcomere reorganization, and protein synthesis ( versus beta-galactosidase )