Gene interactions and pathways from curated databases and text-mining

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KRAS — VEGFA

Text-mined interactions from Literome

Mizukami et al., Cancer Res 2004 (Colonic Neoplasms...) : Thus, VEGF may be induced by hypoxia through HIF dependent and HIF independent pathways, and K-ras also can induce VEGF in hypoxia independent of HIF-1
Li et al., Gastroenterology 2005 (Cell Transformation, Neoplastic...) : The effects of K-ras ( Val12 ) on VEGF and T-cell factor 4 (TCF-4) promoter activity, nuclear levels of beta-catenin and beta-catenin/TCF-4 complexes, glycogen synthase kinase 3beta ( GSK-3beta ) phosphorylation, and GSK-3beta kinase activity were measured ... Oncogenic K-ras up-regulated the activity of the VEGF promoter, and selective mutagenesis of TCF-4 binding sites significantly blocked this induction
Zeng et al., PloS one 2010 (Colonic Neoplasms...) : This activation of K-ras did not depend upon EGFR and resulted in the phosphorylation of Akt and induction of VEGF expression