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KRAS — VEGFA
Text-mined interactions from Literome
Mizukami et al., Cancer Res 2004
(Colonic Neoplasms...) :
Thus,
VEGF may be induced by hypoxia through HIF dependent and HIF independent pathways, and
K-ras also can
induce VEGF in hypoxia independent of HIF-1
Li et al., Gastroenterology 2005
(Cell Transformation, Neoplastic...) :
The
effects of
K-ras ( Val12 ) on
VEGF and T-cell factor 4 (TCF-4) promoter activity, nuclear levels of beta-catenin and beta-catenin/TCF-4 complexes, glycogen synthase kinase 3beta ( GSK-3beta ) phosphorylation, and GSK-3beta kinase activity were measured ... Oncogenic
K-ras up-regulated the activity of the
VEGF promoter, and selective mutagenesis of TCF-4 binding sites significantly blocked this induction
Zeng et al., PloS one 2010
(Colonic Neoplasms...) :
This activation of
K-ras did not depend upon EGFR and
resulted in the phosphorylation of Akt and induction of
VEGF expression