Delgado et al., J Immunol 2000
:
In agreement with the described Janus kinase (Jak)1/Jak2/STAT1/IRF-1 activation pathway, VIP/PACAP inhibit Jak1/Jak2, STAT1 phosphorylation, and the binding of STAT1 to the GAS sequence motif in the IRF-1 promoter
Bartoe et al., Brain Res Mol Brain Res 2002
:
While there are four STAT binding sites within gp130, only those surrounding Y905 and Y915 can mediate STAT1 activation ; these results indicate that STAT1 may be essential for normal gp130 stimulated VIP and ChAT expression