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WLS — WNT2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Port et al., Nat Cell Biol 2008
:
Our results indicate that Wg, clathrin mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling
Wls to
direct Wnt secretion
Fu et al., Proc Natl Acad Sci U S A 2009
:
This suggests that the
Gpr177 mediated
Wnt production can not be substituted ... Our findings demonstrate that the loss of
Gpr177 affects
Wnt production in the signal producing cells, leading to alterations of Wnt signaling in the signal receiving cells
Jin et al., BMC neuroscience 2010
(Opioid-Related Disorders) :
Interaction of the mu-opioid receptor with
GPR177 ( Wntless )
inhibits Wnt secretion : potential implications for opioid dependence ... At the cellular level, morphine treatment caused a shift in the distribution of GPR177 from cytosol to the cell surface, leading to enhanced
MOR/GPR177 complex formation at the cell periphery and the
inhibition of
Wnt protein secretion ... We therefore propose that the morphine mediated
MOR/GPR177 interaction may
result in decreased
Wnt secretion in the CNS, resulting in atrophy of dendritic arbors and decreased neurogenesis
Yu et al., Dev Dyn 2010
:
Expression of
Gpr177 , a
Wnt trafficking
regulator , in mouse embryogenesis
Coombs et al., J Cell Sci 2010
:
WNT secretion
requires its binding to the carrier protein
wntless (WLS) ; we find that WLS is ER-resident in human cells and WNT3A binding to WLS requires PORCN dependent lipid modification of WNT3A at serine 209
Silhankova et al., EMBO J 2010
:
Secretion of
Wnt proteins from producing cells is
mediated by the Wnt binding protein
MIG-14/Wls , which binds Wnt in the Golgi network and transports it to the cell surface for release
Reyes et al., Exp Neurol 2012
:
Wntless (WLS) , a mu-opioid receptor (MOR) interacting protein,
mediates Wnt protein secretion that is critical for neuronal development
Herr et al., Dev Biol 2012
(Wnt Signaling Pathway) :
However, the mechanism by which
Wls promotes
Wnt secretion is a riddle
Augustin et al., EMBO Mol Med 2012
(Brain Neoplasms...) :
We further show that
Evi/Wls overexpression is
sufficient to promote downstream
Wnt signalling
Maruyama et al., J Bone Miner Res 2013
(Osteoporosis) :
Defects in the expansion of skeletal precursors and their differentiation into osteoblasts and chondrocytes suggest that
Wnt production and signaling
mediated by
Gpr177 can not be substituted
Fu et al., J Invest Dermatol 2013
(Wnt Signaling Pathway) :
Here we report that
Wnt production
mediated by
Gpr177 , the mouse Wls ortholog, is essential for hair follicle induction
Maruyama et al., PloS one 2013
(Hyperplasia...) :
Here we report that
Wnt production
mediated by
Gpr177 is essential for mammary morphogenesis
Zhu et al., J Biol Chem 2013
(Wnt Signaling Pathway) :
Gpr177 in the epithelium is
necessary for the activation of canonical
Wnt signaling in the dental epithelium and formation of a functional enamel knot ... Together with the fact that active Wnt canonical signaling is present predominantly in the dental epithelium during tooth development, our results demonstrate that
Gpr177 mediated
Wnt ligands in the dental epithelium act primarily in an intra-epithelial context to regulate enamel knot formation and subsequent tooth development