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EGFR — WNT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EGFR → WNT1 (increases, WNT1 Activity)
  Evidence: Recent studies from our laboratory [63] have shown that treatment of mammary epithelial cells with Wnt-1 or Wnt-5a activates ErbB1 and the MAPK cascade. The effect is rapid and can be blocked by an ErbB1 mAb that interferes with ligand binding, or by metalloproteinase inhibitors. These results suggest that in a manner similar to that described for GPCR agonists, Wnt binding to Fz transactivates ErbB1 by increasing the availability of an ErbB1 ligand. Interestingly, Wnt-transactivated ErbB1 was r...

Text-mined interactions from Literome

Civenni et al., EMBO Rep 2003 : Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells
Schlange et al., Breast Cancer Res 2007 (Breast Neoplasms) : The effects of WNT signaling are mediated partly by EGFR transactivation in human breast cancer cells in a metalloprotease- and Src dependent manner
Hu et al., Molecular cancer 2010 (Neoplasms) : Wnt ligands can activate EGFR signaling through their 7-transmembrane domain receptor Frizzled while EGFR can activate ß-catenin via receptor tyrosine kinase-PI3K/Akt pathway ; EGFR has been shown to form a complex with ß-catenin and increase the invasion and metastasis of cancer cells