Gene interactions and pathways from curated databases and text-mining

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RUNX2 — WNT3

Text-mined interactions from Literome

Gaur et al., J Biol Chem 2005 : Taken together, our results provide evidence for direct regulation of Runx2 by canonical WNT signaling and suggest that Runx2 is a target of beta-catenin/TCF1 for the stimulation of bone formation ... We propose that WNT/TCF1 signaling, like bone morphogenetic protein/transforming growth factor-beta signaling, activates Runx2 gene expression in mesenchymal cells for the control of osteoblast differentiation and skeletal development
Dong et al., J Cell Physiol 2006 (Hypertrophy) : Western blot analysis shows that Wnt8c and beta-catenin also induces Runx2 protein levels in chondrocytes ... Co-transfection of lymphoid enhancer factor ( Lef1 ) and beta-catenin in chicken upper sternal chondrocytes together with deletion constructs of the Runx2 promoter shows that the proximal region spanning the first 128 base pairs of this promoter is responsible for the Wnt mediated induction of Runx2
McCarthy et al., Mol Endocrinol 2010 : Moreover, Wnt pathway induction increases expression of the Runx2-sensitive gene, TGF-beta type I receptor, without increasing nuclear Runx2 levels or Runx2 binding to DNA
Ling et al., J Biol Chem 2010 : Mechanistically, Wnt3a-heparin signaling strongly activates the phosphoinositide 3-kinase/Akt pathway and requires the bone related transcription factor RUNX2 to stimulate alkaline phosphatase activity, which parallels canonical beta-catenin signaling
Liu et al., J Biol Chem 2011 : These data together suggest a molecular mechanism for Ccd1 mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer ( s )
Komori et al., J Cell Biochem 2011 : Wnt signaling upregulates Runx2 expression and activates RUNX2 , and RUNX2 induces Tcf7 expression
Taniguchi et al., J Biol Chem 2011 (Wnt Signaling Pathway) : The expression of Runx2, which plays a major role in late stage chondrocyte differentiation, was enhanced in Hmgb2 ( -/- ) MSC, and HMGB2 negatively regulated the stimulatory effect of Wnt/ß-catenin signaling on the Runx2 proximal promoter