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SLC22A3 — WNT4

Text-mined interactions from Literome

Taki et al., Cancer Sci 2003 (Carcinoma, Squamous Cell...) : To study whether the expressions of these Wnt genes are regulated by EMT , we transfected a Snail-expression vector into A431 and OM-1 cells, which express Wnt-4 but not Wnt-5a ... These results indicated that Wnt-4 and Wnt-5a are oppositely affected by EMT , and down-regulation of Wnt-4 and up-regulation of Wnt-5a are possible markers of the malignant phenotype of human SCC
Nawshad et al., Cells Tissues Organs 2005 (MAP Kinase Signaling System...) : Early studies of the developing embryo have designated the involvement of Wnt signaling in EMT , through an activated complex of the lymphoid enhancing factor-1 (LEF-1) transcription factor and the cell adhesion molecule beta-catenin
Moustakas et al., Cancer Sci 2007 (Cell Transformation, Neoplastic...) : Transforming growth factor-beta, Wnt , Notch and growth factors acting through tyrosine kinase receptors induce EMT and often act in a sequential manner
Chong et al., Exp Eye Res 2009 (Cataract) : Given that Wnt signaling is involved in TGFbeta induced EMT in other systems, this study set out to determine if Wnt signaling has a role in regulating this process in the lens ... Overall, the results from the current study indicate that Wnt signaling is involved in TGFbeta induced EMT and development of fibrotic plaques in the lens
Katoh et al., Curr Pharm Biotechnol 2011 : Because FGF, Hedgehog, TGFß, and non-canonical WNT signals synergistically induce EMT regulators, such as Snail ( SNAI1 ), Slug ( SNAI2 ), TWIST, and ZEB2 ( SIP1 ), tumor-stromal interaction at the invasion front aids cancer stem cells to acquire more malignant phenotype
Emmett et al., Stem Cells Dev 2012 (Wnt Signaling Pathway) : These results suggest that in addition to patterning the early embryo, Geminin plays a previously unrecognized role in EMT via its ability to affect Wnt signaling and E-cadherin expression
Dunlap et al., Cancer prevention research (Philadelphia, Pa.) 2012 (Carcinoma, Basal Cell...) : Conversely, CR suppressed M-Wnt and E-Wnt tumor progression ( P < 0.02, each ) and inhibited EMT and intratumoral adipocyte accumulation
Zhang et al., Carcinogenesis 2013 (Carcinoma, Hepatocellular...) : Our results suggest that Wnt/ß-catenin signaling enhances hypoxia induced EMT in HCC by increasing the EMT associated activity of hif-1a and preventing tumor cell death
Wang et al., Pathol Oncol Res 2013 : Overexpression of galectin-3 promoted Tca8113 cell proliferation, migration and invasion, upregulated Wnt protein expression, activated ß-catenin and induced the EMT ; knockdown of galectin-3 had the opposite effects
Kanzawa et al., Pathobiology 2013 : Conclusions : WNT5A regulates the induction of EMT and the maintenance of CSC properties in MKN-7 cells