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WNT2 — WNT4
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Le Floch et al., FASEB J 2005
(Colonic Neoplasms...) :
Upstream
activation of
Wnt signaling by the Wnt-2 and Wnt-3a ligands, stable overexpression of
Wnt-2 , as well as GSK-3beta inhibition by lithium, SB216763, and GSK-3beta dominant negative forms ( K85R and R96E ) conferred the invasive phenotype through several proinvasive pathways
Shi et al., Int J Cancer 2007
(Colorectal Neoplasms) :
In this study, we investigated
roles of
Wnt-2 and Gal-3 in the regulation of canonical
Wnt/beta-catenin signaling
Bayle et al., J Invest Dermatol 2008
(Scleroderma, Systemic) :
Increased expression of
Wnt2 and SFRP4 in Tsk mouse skin :
role of
Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis
Tamashiro et al., Biochim Biophys Acta 2008
:
By contrast, female sex determination depends on the action of Rspo1 and
Wnt4 , the
regulators of
Wnt/beta-catenin signaling
Krützfeldt et al., Diabetologia 2010
(Diabetes Mellitus, Type 2...) :
Increased expression of
WNT4 inhibited canonical
WNT signalling in pancreatic islets and MIN6 cells
Wang et al., PLoS Genet 2013
(Azoospermia...) :
Further studies found that the expression of cell polarity associated genes ( Par6b and E-cadherin ) and
Wnt signaling genes ( Wnt4, Wnt11 ) were downregulated in Wt1 deficient SCs, and that the expression of Par6b and E-cadherin was
regulated by
Wnt4