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NTF4 — WT1
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Eggert et al., J Clin Oncol 2001
(Kidney Neoplasms...) :
To study the
role of
neurotrophin receptors and ligands in
Wilms ' tumor ( WT ) , we determined their expression by semiquantitative duplex reverse transcriptase polymerase chain reaction in 39 patients with primary WT. Comparison of mRNA expression levels with clinical variables was performed by use of Cox regression analysis
Wagner et al., Genes Dev 2005
:
Coronary vessel development requires
activation of the TrkB
neurotrophin receptor by the Wilms ' tumor transcription factor
Wt1 ... These findings demonstrate that transcriptional
activation of the TrkB
neurotrophin receptor gene by the Wilms ' tumor suppressor
Wt1 is a crucial mechanism for normal vascularization of the developing heart