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TNF — XIAP

Text-mined interactions from Literome

Nakamura et al., Lab Invest 2000 (Sjogren's Syndrome) : However, XIAP expression was down-regulated by TNF-alpha , which induced apoptotic cell death of HSG cells with an increase in caspase-3 activity
Xiao et al., Endocrinology 2001 : Western analysis indicated that TNFalpha alone increased the Xiap protein level, a response significantly reduced by adenoviral Xiap antisense expression
Ferroni et al., J Immunother 2001 (Inflammation...) : On the other hand, ILP with cytotoxic drugs alone induced only a modest release of TNFalpha , which was not followed by an immediate rise in IL-6 and IL-8
Hentze et al., Hepatology 2004 : CPT treatment completely abrogated the TNF induced NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2, FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also inhibited by CPT. The caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Kim et al., Biochem Biophys Res Commun 2005 (Insulinoma...) : Here, we found that : ( i ) XIAP level was inversely correlated with tumor necrosis factor (TNF)-alpha induced apoptosis in MIN6N8 insulinoma cells ; ( ii ) adenoviral XIAP overexpression abrogated the TNF-alpha induced apoptosis through inhibition of caspase activity ; ( iii ) downregulation of XIAP by antisense oligonucleotide or Smac peptide sensitized MIN6N8 cells to TNF-alpha induced apoptosis ; ( iv ) XIAP expression was induced by TNF-alpha through a nuclear factor-kappaB (NF-kappaB) dependent pathway, and interferon (IFN)-gamma prevented such an induction in a manner independent of NF-kappaB, which presents a potential mechanism underlying cytotoxic IFN-gamma/TNF-alpha synergism
Takada et al., Oncogene 2007 : TNF induced the expression of NF-kappaB regulated gene products cyclin D1, c-Myc, matrix metalloproteinase-9, survivin, X-linked inhibitor-of-apoptosis protein ( IAP ), IAP1, Bcl-x ( L ), A1/Bfl-1 and Fas associated death domain protein-like IL-1beta converting enzyme-inhibitory protein in wild-type MEF but not in PKR-/- cells
Furusu et al., J Cell Physiol 2007 : In human endothelial cells, TNF-alpha induced c-IAP1 and c-IAP2, but not XIAP and TIAP/Survivin, at the transcriptional level
Qin et al., Cell Mol Immunol 2007 (Acute Disease...) : Furthermore, TNF-alpha up-regulated X-linked inhibitor of apoptosis protein ( XIAP ) transiently and XIAP levels were correlated with the temporal pattern of TNF-alpha protection against Fas mediated apoptosis
Kim et al., Diabetes 2007 (Diabetes Mellitus, Type 1) : The induction of X-linked inhibitor of apoptosis protein by TNF-alpha was inhibited by IFN-gamma in STAT1 ( +/- ) islet cells but not in STAT1 ( -/- ) islet cells
Ahn et al., Cancer Res 2007 (Skin Neoplasms) : The induction of various antiapoptotic gene products ( MMP-9, cyclin D1, COX-2, IAP1, IAP2, Bcl-2, cFLIP, and XIAP ) by TNF was also abolished in NQO2-/- cells
Van Themsche et al., Endocrinology 2008 (Carcinoma...) : On the opposite, TNFalpha up-regulated XIAP in Hec-1A cells ; in these cells, the cytokine induced delayed TNF-R1 dependent activation of caspase-8, and failed to activate caspases -9 and -3 and to induce apoptosis ... In addition, inhibition of protein kinase C activity enhanced TNFalpha induced down-regulation of XIAP and potentiated apoptosis induction, in both Ishikawa and Hec-1A cells
Park et al., Biochem Pharmacol 2011 (Inflammation...) : Triptolide also abrogated TNF induced expression of cell survival proteins ( XIAP , Bcl-x ( L ), Bcl-2, survivin, cIAP-1 and cIAP-2 ), cell proliferative proteins ( cyclin D1, c-myc and cyclooxygenase-2 ), and metastasis proteins ( ICAM-1 and MMP-9 )