Gene interactions and pathways from curated databases and text-mining

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CD46 — TNF

Text-mined interactions from Literome

Mason et al., Blood 1999 : Tumor necrosis factor alpha (TNFalpha) and interferon gamma (IFNgamma) each increased DAF expression but not CD59 or MCP expression, and a combination of these cytokines was more potent than either alone
Murugesan et al., J Biomed Mater Res 2000 : Endothelial cells ( EC ) from human aortas, microvessels, and pulmonary arteries were examined for their expression and activity of monocyte chemotactic protein-1 (MCP-1) , tissue factor, and thrombomodulin in response to tumor necrosis factor-alpha (TNFalpha) on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ), along with a fibronectin ( FN ) control
Narumi et al., Cytokine 2000 : On the other hand, JE/MCP-1 mRNA expression was detected only in non-parenchymal cells in response to TNF-alpha and IL-1beta, but not in response to IFN-gamma
Carpenter et al., BMC infectious diseases 2002 (Lung Neoplasms) : In this study, we examined the NF-kappaB mediated effects of RSV and the proinflammatory cytokine TNFalpha on the induction of IL-8, MCP-1 and RANTES chemokine gene expression in A549 epithelial cells
Wise et al., Arch Oral Biol 2003 : TNF-alpha itself enhanced monocyte chemotactic protein 1 (MCP-1) and vascular endothelial growth factor ( VEGF ) gene expression
Chiu et al., Chin J Physiol 2002 : The TNF-alpha induced monocyte chemotactic protein-1 (MCP-1) mRNA expressions were significantly attenuated in ECs subjected to a high level of shear stress ( 20 dynes/cm2 ) for 4 or 24 h prior to the addition of TNF-alpha in the presence of flow
Colotta et al., J Immunol 1992 : IL-1, TNF , IFN-gamma, granulocyte-macrophage-CSF and, to a lesser extent, macrophage-CSF, as well as inactivated streptococci, also induced MCP gene expression
Shi et al., Cell Biochem Biophys 2004 (Atherosclerosis) : We observed constitutive expression of interleukin (IL)-6, IL-8, granulocyte macrophage colony stimulating factor ( GM-CSF ), and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells, and these cytokines were further induced by TNF-alpha and LPS
Jiang et al., Free radical research 2004 : The mRNA accumulation of IL-8, MCP-1 , RANTES, and eotaxin, and activation of NF-kappaB were induced by TNF-alpha for 2 h ; all were suppressed significantly by the above two pretreatments
Liu et al., Am J Respir Cell Mol Biol 2005 (Lung Diseases) : In vitro analysis indicates that alveolar cell expression of TNF-R2 is critical in the induction of epithelial monocyte chemoattractant protein (MCP)-1 expression specifically in response to soluble TNF-alpha , suggesting an important role for this receptor in bystander lung injury
Chen et al., Am J Physiol Heart Circ Physiol 2006 : Nrf2 suppressed TNF-alpha induced monocyte chemoattractant protein (MCP)-1 and VCAM-1 mRNA and protein expression in a dose dependent manner and inhibited TNF-alpha induced monocytic U937 cell adhesion to HAECs
Yamamoto et al., Toxicol Appl Pharmacol 2006 (Pneumonia) : LTA produced a dose related increase in early pulmonary inflammation, which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6, tumor necrosis factor (TNF)-alpha , macrophage inflammatory protein (MIP)-1alpha/CCL3, but no effect on monocyte chemoattractant protein (MCP)-1/CCL2 at 24 h after instillation
Wang et al., Pflugers Arch 2006 (Inflammation) : The adipokine secretion pattern largely paralleled cellular mRNA levels ; IL-6 ( transiently ), MCP-1 , NGF and VEGF release were stimulated by TNF-alpha , with an accelerating rate of MCP-1 secretion over 24 h. TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes, with highly gene-specific responses
Leonardi et al., Clin Exp Allergy 2006 (Conjunctivitis, Allergic) : IL-6, IL-8, MCP-1 , RANTES and eotaxin were detected from fibroblasts cultures, and were all up-regulated by TNF-alpha
Nanua et al., Am J Respir Cell Mol Biol 2006 : Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha induced IL-8 and monocyte chemoattractant protein (MCP)-1 ( also called CCL2 ) expression in cultured human airway epithelial cells
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation...) : H/R ( 3 h/1 h ) significantly induced KC, MCP-1 , macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha , MCP-1, RANTES, MIP-1alpha, and MIP-2 ( but not KC ) by RAW264.7 cells ... Importantly, using macrophage and epithelial coculture methods, the specific production of TNF-alpha by H/R exposed RAW264.7 cells significantly induced proinflammatory cytokine/chemokine expression ( KC, MCP-1 , MIP-2, RANTES, and IL-6 ) by MLE-12 cells
Elizur et al., Am J Respir Cell Mol Biol 2008 : Using a transformed murine Clara cell line ( C22 ), we observed that both LPS and TNF-alpha induced production of keratinocyte derived chemokine ( KC ) and monocyte chemoattractant protein (MCP)-1
Sun et al., Am J Physiol Gastrointest Liver Physiol 2007 (Pancreatitis) : In the presence of TNF-alpha , MCP-1 was upregulated
Kim et al., Eur J Pharmacol 2009 (Inflammatory Bowel Diseases) : TNF-alpha induced mRNA induction of the chemokines, monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8, and the intercellular cell adhesion molecule ( ICAM)-1, which are involved in adhesion between leukocytes and epithelial cells, was suppressed by M1-M4, and M1 was the most efficacious
Mahtout et al., FEMS Immunol Med Microbiol 2011 : Although these two cytokines had no effect on CD46 and CD55 gene expression in epithelial cells, IL-1ß and tumor necrosis factor-a induced a significant upregulation
Honda et al., Anticancer Res 2011 (Colonic Neoplasms...) : RESULTS : In THP-1 cells, monocyte chemotactic protein (MCP)-1 mRNA expression increased in a time dependent manner from day 3 after co-culture with DLD-1 cells ; furthermore, expression of vascular endothelial growth factor ( VEGF ) -A, tumor necrosis factor (TNF)-a , interleukin (IL)-1ß, and IL-8 mRNA was increased from day 5
Kim et al., J Nutr Biochem 2012 (Myocardial Infarction...) : In CMs, TLR2 and monocyte chemoattractant protein (MCP)-1 mRNAs were increased by TNF-a , PGN or H/R, whereas they were blunted by curcumin
Lee et al., International journal of molecular sciences 2012 : AP also effectively reduced TNF-a induced mRNA expressions of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 in a dose dependent manner
Bjørge et al., Cancer Immunol Immunother 1996 (Adenocarcinoma...) : MCP expression was up-regulated by IL-1 beta, but not by TNF alpha or INF gamma
Sato et al., J Rheumatol 1996 (Arthritis, Rheumatoid) : TNF-alpha increased the expression of IL-8, MCP-1 , and collagenase mRNA in human synovial cells
Huang et al., J Immunol 1998 (Peritonitis) : Mouse MCP-6 did not induce cultured human endothelial cells to express TNF-alpha , RANTES, IL-1alpha, or IL-6