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CXADR — TNF

Text-mined interactions from Literome

Abdullah et al., American journal of physiology. Renal physiology 2006 : Cyclosporine A ( CsA ), an inhibitor of the serine/threonine phosphatase calcineurin, and a peptide ligand, VIVIT, that selectively inhibits calcineurin-NFAT signaling, also prevented CaR mediated TNF production ... Collectively, these data verify the role of calcineurin and NFAT in CaR mediated TNF production by mTAL cells
Abdullah et al., American journal of physiology. Renal physiology 2008 : CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism ... CaR mediated TNF production also was partially reversed by a cAMP analog, 8-Br-cAMP ... The interaction between G ( i ) and PKC was determined, as we previously showed that CaR mediated TNF production was CaN and NFAT- mediated and G ( q ) dependent ... Moreover, concurrent G ( q ) and G ( i ) signaling is required for CaR mediated TNF production in mTAL cells via a CaN/NFAT pathway that is PKC dependent
Hao et al., American journal of physiology. Renal physiology 2009 : Expression of NFAT5 was increased in mTAL cells transiently transfected with an NFAT5 overexpression vector ( pcDNA3.1-NFAT5 ), resulting in increased basal and calcium sensing receptor (CaR) mediated TNF production