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IFI16 — TP53

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TP53 → Complex of IFI16-TP53 (increases, IFI16/TP53 Activity) Gugliesi et al., J Leukoc Biol 2005*
  Evidence: binding to IFI16 resulted in its transcriptional activation as shown by an increase in the activity of a reporter gene driven by p53-responsive sequences derived from the p21(WAF1) promoter, along with an increase in the p21 mRNA and protein levels.
• WikiPathways Senescence and Autophagy in Cancer: IFI16 → TP53 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IFI16 — TP53 (physical association, affinity chromatography technology) Johnstone et al., Oncogene 2000*
• IRef Dip Interaction: TP53 — IFI16 (direct interaction, pull down) Liao et al., Structure 2011*
• IRef Dip Interaction: TP53 — IFI16 (direct interaction, classical fluorescence spectroscopy) Liao et al., Structure 2011*
• IRef Hprd Interaction: TP53 — IFI16 (in vivo) Johnstone et al., Oncogene 2000*
• IRef Intact Interaction: TP53 — IFI16 (physical association, pull down) Johnstone et al., Oncogene 2000*
• IRef Intact Interaction: TP53 — IFI16 (direct interaction, pull down) Johnstone et al., Oncogene 2000*
• IRef Intact Interaction: TP53 — IFI16 (physical association, confocal microscopy) Johnstone et al., Oncogene 2000*
• IRef Intact Interaction: TP53 — IFI16 (physical association, anti bait coimmunoprecipitation) Johnstone et al., Oncogene 2000*
• IRef Ophid Interaction: TP53 — IFI16 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TP53 — IFI16 (aggregation, confirmational text mining) Johnstone et al., Oncogene 2000*

Text-mined interactions from Literome

Kwak et al., J Biol Chem 2003 : Here we report that the inhibition of endogenous IFI16 expression by small interfering RNA ( siRNA ) induces p21Waf1 mRNA and protein expression through p53 but does not induce pro-apoptotic p53 target genes ... We also showed that the repression of IFI16 affects p53 transcriptional activity at the p21 promoter as well as the protein stability of p53 and p21
Gugliesi et al., J Leukoc Biol 2005 : Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells
Tawara et al., Frontiers in bioscience : a journal and virtual library 2008 : Our previous results that IFI16 is involved in p53 transcription activity under conditions of ionizing radiation ( IR ), and that the protein is frequently lost in human breast cancer cell lines and breast adenocarcinoma tissues suggesting that IFI16 plays a crucial role in controlling cell growth
Song et al., Mol Cancer Res 2008 : Expression of an IFN-inducible cellular senescence gene, IFI16 , is up-regulated by p53 ... Expression of an IFN-inducible cellular senescence gene, IFI16 , is up-regulated by p53 ... Here, we reported that functional activation of p53 in normal young HDFs and p53-null Saos2 cell line resulted in transcriptional activation of the IFI16 gene ... Interestingly, p53 associated with the regulatory region of the IFI16 gene only on treatment of cells with DNA damaging agents or in the old, but not in the young, HDFs. Importantly, our promoter-reporter assays, which were coupled with site directed mutagenesis of IFI16-p53-BS, showed that p53 activates transcription of the IFI16 gene in HDFs through the p53 DNA binding site ... Together, our observations provide support for the idea that up-regulation of IFI16 expression by p53 and functional interactions between IFI16 protein and p53 contribute to cellular senescence
Liao et al., Structure 2011 : Both interactions are compatible with the DNA bound state of p53 and together contribute to the effect of full-length IFI16 on p53-DNA complex formation and transcriptional activation