Gene interactions and pathways from curated databases and text-mining

◀ Back to TNF

ITGB3 — TNF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → TNF (increases, TNF Activity)
    Evidence: To determine the mechanism by which IL-18 mediates angiogenesis, we hypothesized that IL-18 may act through integrins present on HMVECs. TNF-a is angiogenic in part via its action on integrin avb3 (34). Thus, we examined whether blocking avb3 would inhibit IL-18-induced angiogenesis in the HMVEC migration assay. HMVECs were first incubated with anti-avb3 Ab or nonspecific control IgG at 25 mg/ml for 1 h before and during the chemotaxis assay. IL-18 (10 nM) was then used to stimulate HMVEC migrat...
  • OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → TNF (increases)
    Evidence: alpha2beta1 is upregulated by VEGF, alphaVbeta3 and alpha5beta1 are not, but instead are induced by bFGF, TNF and other angiogenic cytokines

Text-mined interactions from Literome

Dellacasagrande et al., Infect Immun 2000 : The monocyte alpha(v)beta(3) integrin was involved in TNF synthesis since peptides containing RGD sequences and blocking antibodies against alpha(v)beta(3) integrin inhibited TNF transcripts induced by C. burnetii ... Nevertheless, the cross linking of alpha(v)beta(3) integrin by specific antibodies was not sufficient to induce TNF synthesis
Neidhart et al., Ann Rheum Dis 2005 (Arthritis, Rheumatoid) : TNF alpha reduced the expression of CD61 and the adhesion to COMP, but did not reverse the adhesion once it had taken place