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KLF2 — TP53

Text-mined interactions from Literome

Kumar et al., Arterioscler Thromb Vasc Biol 2011 : To evaluate if p53 decreases Kruppel-Like Factor 2 (KLF2) expression and determine whether p53 mediated suppression of KLF2 plays a role in p53 induced endothelial dysfunction ... The effect of p53 on KLF2 expression was determined ... p53 inhibited KLF2 transcription in a histone deacetylase dependent and a histone acetyltransferase independent fashion ... KLF2 expression was suppressed by p53 via a conserved p53 binding repressor sequence in its promoter ... These findings illustrate a novel p53 dependent mechanism for the regulation of endothelial KLF2 expression
Heo et al., Arterioscler Thromb Vasc Biol 2013 (Inflammation) : Because nuclear p53 can inhibit Kruppel-like factor 2 promoter activity, we investigated the roles for PIAS1 phosphorylation and p53-SUMOylation in the Kruppel-like factor 2 and endothelial NO synthase expression