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PAX3 — TP53

Text-mined interactions from Literome

Pani et al., Genes Dev 2002 (Neural Tube Defects) : Pax-3 deficiency had no effect on p53 mRNA, but increased p53 protein levels
Underwood et al., FEBS Lett 2007 : Studies from murine embryogenesis and cancer cells derived from human melanomas have identified a critical role for the transcription factor PAX3 in the suppression of p53 protein accumulation and p53 dependent apoptosis ... We define the functional domains of PAX3 required for this activity, and furthermore present evidence that PAX3 dependent inhibition of p53 is independent of binding of the N-terminal domain of p53 to HDM2, the primary negative regulator of cellular p53 activity
Wang et al., PloS one 2011 : Pax3 stimulates p53 ubiquitination and degradation independent of transcription ... The paired domain and homeodomain each stimulated Mdm2 mediated ubiquitination of p53 and p53 degradation in the absence of the Pax3 transcription regulatory domains, whereas Splotch Pax3 did not stimulate p53 ubiquitination or degradation ... Because inactivating p53 is the only required Pax3 function during neural tube closure and cardiac neural crest development, and inactivating p53 does not require Pax3 dependent transcription regulation, this indicates that Pax3 is not required to function as a transcription factor during neural tube closure and cardiac neural crest development